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Research programmes

Connecting perspectives: from bytes and molecules to organisms and populations

"We are committed to promoting research that is useful for the health of citizens as well as producing a new generation of knowledge, created through interdisciplinarity".

Jordi Camí, General Director of the PRBB.

The PRBB's research centres, with almost 30 scientific programmes and 200 principal investigators, study the mysteries of living systems and human health.

With a comprehensive approach, from the molecular to the populational perspective, scientists and experts in their respective fields meet, discuss and collaborate within this building, generating synergies and productive cross-pollination.


Hospital del Mar Medical Research Institute (IMIM)

Cancer

The cancer research programme aims to help improve the prevention and diagnosis of this disease, as well as increase cure rates and quality of life through research. The research groups are classified into three complementary levels: basic, preclinical and disease-oriented research

Epidemiology and Public Health

The EPISAP researchers apply advanced epidemiological methods and approaches to achieve a better understanding of: (a) a disease frequency and burden; (b) the major risk factors and their underlying mechanisms; and (c) the role of surgery and the healthcare services and the impact these have on health outcomes in both individuals and populations.

Biomedical Informatics

This programme carries out fundamental research and develops technology for applying advanced information technologies and computational methods to the health and life sciences. Together with Farmaindustria, it coordinates the Spanish Technological Platform for Innovative Medicines (Plataforma Tecnológica Española de Medicamentos Innovadores; PTEMI) and is the Biomedical Informatics node of the National Bioinformatics Institute (Instituto Nacional de Bioinformática; INB). 

Neuroscience

The programme’s mission is to support clinical research, which should ultimately give us a better understanding of mental illnesses and neurodegenerative diseases.

Translational Clinical Research

The Translational Clinical Research Program (Research in Inflammatory and Cardiovascular Disorders Program before) combines the effort, knowledge and know-how of the 40 investigators and more than 100 technicians and support personnel of 15 research groups committed to the expansion of the knowledge on the physio-pathological, inflammatory and genetic mechanisms of cardiovascular, respiratory, bone and other acute and chronic disorders, their treatment and management.

Department of Experimental and Health Sciences at Pompeu Fabra University (DCEXS-UPF)

Cellular and Molecular Biology

The research activities in this programme concern the molecules within cells, the interactions between these, and their role in the function of individual cells and living organisms. The programme covers a wide range of disciplines including cellular and molecular biology, physiology, genomics, microbiology, immunology, proteomics, neurobiology and pathology.

Molecular Medicine

This programme brings together several research groups with diverse but overlapping scientific interests, with the aim of deciphering the molecular mechanisms underlying physiological pathways and the diseases associated with these. Both normal and pathological processes are studied from different disciplines (molecular biology, immunology, biochemistry, proteomics and neurobiology) using unicellular and multicellular model organisms.

Evolutionary Biology and Complex Systems

The programme comprises various interdisciplinary groups focused on the processes and mechanisms that generate all aspects of life's diversity, especially those related to its complexity. The study subjects cover a wide range of natural and artificial elements, from individual genes, molecules, pathways, cells and genomes to organisms, populations, species and entire ecosystems.

Biomedical Informatics

The Research Programme on Biomedical Informatics (GRIB) is a joint research programme run by the IMIM and Pompeu Fabra University (Universitat Pompeu Fabra; UPF). They carry out fundamental research and develop technology for applying information technologies and computational methods to life and health sciences.

Genetics and Neuroscience

The scientific goal of this programme is to understand the genetic and molecular basis of nervous system development, function and disease. The programme covers three main areas: Developmental neurobiology, the genetics of cognitive functions and neuropharmacology.

Systems Bioengineering

The research groups that make up this programme are dedicated to acquiring and interpreting quantitative knowledge of biological processes using systems-level approaches, and using this knowledge to control and act on cells and their environment. To achieve this vision, the programme employs an interdisciplinary approach that combines cell and molecular systems biology, synthetic biology, computational and mathematical modelling, biophysics, biomaterials and nanobiomedicine.

Transversal Program

Whether a person is healthy or not is determined by their circumstances and environment. Health determinants include an individual's social and economic environment, the physical environment, and individual characteristics and behaviour. The programme is primarily dedicated to epidemiological research on the determinants of occupational, environmental and social health, and to providing scientific knowledge relevant to public health action for reducing health inequalities.

Centre for Genomic Regulation (CRG)

Bioinformatics and Genomics

Genomic technology is generating an extraordinary amount of information, unprecedented in the history of biology. Bioinformatics addresses the specific data acquisition, storage, analysis and integration needs generated by genomics research. The programme groups cover a wide range of topics: from the computational biology of RNA processing, comparative bioinformatics and comparative genomics to gene function and evolution and genomic and epigenomic variation in disease. The programme also plays host to the EGA team at the CRG, which together with the EMBL-EBI, manages the European Genome-Phenome Archive (EGA).

Cell and Developmental Biology

The programme focuses on the interactions between intercellular signalling systems and the cytoskeleton, and how this contributes to the spatial organisation and information processing capacity of cells and groups of cells. It centres on systems with strong genetics (Drosophila and zebrafish) and uses multidimensional phenotypes based on genomics and proteomics.

Gene Regulation, Stem Cells and Cancer

The interests of the scientists in this programme range from the mechanisms of gene expression and epigenetic regulation to the molecular basis of the cell decisions involved in tissue homeostasis and cancer. Mechanistic and biological studies of gene regulation cover the entire gene expression pathway, from the organisation of chromatin in the cell nucleus to the translation of mRNA in the cytoplasm. In addition, cell reprogramming research includes differentiation and transdifferentiation studies in various systems.

Systems Biology

The programme's research groups cover a wide range of topics: from dynamic gene regulation networks to systems neuroscience, and employ a wide range of model systems to address these problems, including prokaryotes, cell lines, C. elegans, Drosophila and mice. The programme is strongly interdisciplinary, involving a growing number of physicists, mathematicians and computer scientists, as well as biologists.

Medical Genomics

Understanding how our genome functions offers unrivalled opportunities to transform medicine. By providing insights into the genetic mechanisms of disease, it enables the development of more efficient preventive or curative therapies. The Medical Genomics Programme acts as an innovation hub for CRG´s cross-cutting efforts to understand human disease. It fosters partnerships and creates collaborative forums within CRG and across partner institutions, including research centres, clinical scientists, and industry. 


Barcelona Institute for Global Health (ISGlobal, Mar Campus)

Climate and Health

Climate change is becoming a major issue for public health and features in global political agendas. The programme's scientific work focuses on the effects that the environmental consequences of climate change may have on human health, as well as the development of predictive computer models.

Air pollution and urban environment

The programme includes exposure assessment; epidemiological and health impact studies on a variety of urban exposures, including air pollution, noise, temperature, natural environments (green and blue spaces), and lifestyle, such as active transport and physical activity. The programme's main objectives are to achieve a better understanding of where and how exposure takes place, how it influences health, and what the likely disease burden is. Our work uses a combination of innovative tools such as geographic information systems, satellite data and smartphone technology to estimate people's exposure.

Non-communicable diseases and the environment

The programme focuses on the causes and mechanisms of cancer and respiratory and allergic disease development and progression throughout life in low- and high-income countries, focusing on environmental, occupational and lifestyle determinants, and incorporating advanced epidemiological, bioinformatic and statistical methods.

Childhood and Environment

This programme assesses the effects of environmental contaminants on the health of children, particularly following exposure during intrauterine and postnatal periods. This is considered an international priority.

Radiation

The overall goal of the programme is to develop a better understanding of the potential risks associated with radiation exposure. Ultimately, this serves to protect the general population, patients and people exposed as a result of their work, and to inform policies for achieving this objective. Another programme aim is to boost the way we monitor populations affected by nuclear accidents, in the past and future, and improve their living conditions.

Other

ISGlobal develops other research programmes on their Clínic Campus: Chagas and parasitic and imported diseases; viral and bacterial infections; malaria; and maternal, child and reproductive health.

Institute of Evolutionary Biology (IBE: CSIC-UPF)

Animal Biodiversity and Evolution

The members of this research programme study animal biodiversity from a phylogenetic perspective with the aim of obtaining a greater understanding of the tree of life. Specific research interests include the origin and distribution of biodiversity, group systematics, speciation, hybridisation, diversification, biogeography, evolutionary ecology, and phylogenetic methods.

Comparative and Computational Genomics

This programme compares genomes at the intra- and interspecific level with the general aim of understanding genome dynamics, reconstructing the evolutionary processes that generate biodiversity and linking genomic and phenotypic differences between individuals and species. To achieve these objectives, they implement experimental studies and theoretical/numerical approaches, with a strong emphasis on computational techniques.

Functional Genomics and Evolution

The synthesis of evolution, palaeontology, genomics and development led to the new field of Evolution and Development (referred to as EvoDevo). The aim of EvoDevo is to address basic evolutionary questions taking into account embryological data but with a broader comparative perspective. The programme takes a step forward, combining evo-devo analysis with functional genomic approaches. The goal is to study fundamental biological issues such as the evolution of multicellularity, development, growth, metamorphosis and ovogenesis.

Population genetics

Genetic diversity is the result of the intricate interaction of several processes: some are embedded into the genome, such as mutation and recombination, others may be the result of natural selection. In this programme, all three of these processes are studied in humans. They investigate how recombination may be affected by genetic differences between populations; the demographic histories of particular populations or populational groups, such as the Bantu expansion; and the extent to which humans adapt to their pathogenic environment.

Complex Systems

This programme includes the study of the evolution of complex systems, both natural and artificial, with the aim of identifying general organisational rules. The research in this programme can be expanded to a wide range of different systems. Special emphasis is placed on the study of computational biology, the biology of protocells, synthetic systems and network biology, specifically the dynamics of viruses, tissue architecture, ecological networks, cancer systems and language networks.

European Molecular Biology Laboratory (EMBL)

Tissue biology and disease modelling

The scientists in this unit explore how tissues and organs function and develop, in terms of health and disease. They examine questions such as “How do molecular and genetic networks ultimately build, regulate and control tissues and organs?”, and “How do changes in genes filter through cells, tissues and organs to cause disease?”

Institute of Applied Radiopharmacy of Barcelona (IRAB)

Research and Innovation

The commitment to research and innovation in radiopharmacy is one of this unit's founding goals, with a clear objective: to work together with the region's biomedical network to develop and facilitate next-generation radiopharmaceuticals that improve quality of care and the life of patients.


Animal facility

Animal research with the international accreditation from the AAALAC.

The PRBB Animal Facility supports the animal experimentation carried out by the centres and is one of the most complex and automated in Europe. Its 4,500 m2 are organised into six areas that house mice, rats, zebrafish (Danio rerio) and Xenopus frogs.

Animal welfare is one of the PRBB’s fundamental commitments. That is why, in addition to complying with the corresponding official regulations, the animal facility has expert veterinary staff who ensure optimal animal health and welfare conditions.

  • Anyone performing an experiment involving animals must take a special course, and all studies must be pre-approved by the Ethics Committee for Animal Experiments (CEEA-PRBB).
  • The PRBB laboratory animal care and use programme is fully accredited by the International Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC). This is the highest international certification in this field and recognises the quality of the centre's operation, which translates into better practices and research results, as well as improved animal welfare.
  • The PRBB has signed the Transparency Agreement for the Use of Animals in Scientific Experiments, promoted by the Confederation of Scientific Societies of Spain (Confederación de Sociedades Científicas de España; COSCE) in collaboration with the European Animal Research Association (EARA).

For more information on the animal facility and animal experimentation visit:

⟶ recercaambanimals.prbb.org

⟶ estabulari-prbb@prbb.org

⟶ Animal Facility: Services and Price rates

Animal experimentation courses

The PRBB and Charles River Campus

Anyone who wishes to undertake an experiment involving animals must take an experimental animal user training course.
Enroll before November 6 for the next course.

The PRBB animal facility, in collaboration with Charles River, organises courses, accredited by the Generalitat de Catalunya and designed for the park's residents, to train them in:

  • Euthanasia (Function b)
  • Performing procedures (Function c)
  • Designing projects and procedures (mice and fish/amphibians) (Function d)

The courses are taught partly online, in Spanish or English. The theoretical part is online and the practical classes are given in the PRBB facilities.

More information about the courses:

Register to courses:

⟶ Download Form

Latest news


Scientific and technical services

Shared facilities for high-impact research

"Actions at the park are developed with pragmatism. Each centre lends its experience and shares it with the others."

Jordi Camí, General Director of the PRBB

The PRBB inter-institutional coalition allows all the scientists to obtain support from a wide variety of platforms with state-of-the-art equipment and led by experts in the field. The service units continuously explore new and emerging technologies, including for data interpretation and representation. In addition, most units organise courses for the researchers to help them become familiar with the technology. With the exception of the PRBB Animal Facility, all the services are managed by the centres.

The MARBiobanc unit holds several biological sample collections designed for biomedical research purposes and it is organised as a technical unit with standards of quality, order and purpose. The service includes cryopreservation, sample processing, and laser microdissection

Contact: Núria Somoza
marbiobanc@imim.es

Web:
https://marbiobanc.imim.es

The Biocore unit provides external researchers and organisations with consulting services, planning for Next Generation Sequencing (NGS) and other genomic experiments, NGS data processing, analysis and management, software and database development, bioinformatics training and access to high-throughput computing resources.

Contact: Julia Ponomarenko
biocore@crg.eu

Web:
https://biocore.crg.eu

The CNAG-CRG is an institute specialising in massive sequencing and genomic analysis, and is located within Barcelona Science Park (PCB). Sequencing and data analysis projects span research areas including cancer genetics, rare diseases, host-pathogen interactions, evolutionary studies and the improvement of species of agricultural interest, in collaboration with scientists from universities, hospitals and research centres, as well as biotechnology and pharmaceutical companies.

Contact: Ivo Gut
projectmanager@cnag.crg.eu

Web:
https://www.cnag.crg.eu

This is a comprehensive service that includes different cytogenetic analysis techniques: conventional cytogenetics; fluorescence in situ hybridisation (FISH); and multicolour spectral karyotyping (SKY) of human or mouse chromosomes. These three techniques can be complemented with the microarray technique (Affymetrix ®) by hybridising cytogenetic chips.

Contact: Blanca Espinet
bespinet@parcdesalutmar.cat

Web:
https://www.imim.es/sct/citogen_tica

This technology makes it possible to study a number of individual particle parameters simultaneously and quickly. It is useful for studying cell surface receptors, nuclear and cytoplasmic antigens, DNA content, enzyme activity, cell integrity and membrane permeability, and calcium flow. The unit currently houses five analysers and two classifiers, and is the largest Becton Dickinson site in Spain.

Contact: Òscar Fornas
oscar.fornas@upf.edu

Web:
https://www.crg.eu/en/core/programmes-groups/crgupf-facs-unit

The main purpose of the CEEA-PRBB is to evaluate experimental procedures using animals with the ultimate aim of avoiding unnecessary suffering. This evaluation takes into account: - the suitability of the procedure in relation to the study objectives. - the possibility of reaching valid conclusions with as few animals as possible. - the fact that the effect on animals is not disproportionate to the potential benefits of the research. - the possibility of employing alternative methods to the use of animals.

Contact: Dirección de secretaría
ceea@prbb.org

Web:
https://www.prbb.org/ciencia.php#Animalario

This technological platform offers protein production and automated biochemical and biomolecular detection processes. Other techniques include the production of clones, mutants and plasmid libraries, protein and antibody purification, and the biophysical characterisation of proteins and nucleic acids. ©Tecan. ©ThermoFisher.

Contact: Carlo Carolis
bmspt@crg.eu

Web:
https://www.crg.eu/en/programmes-groups/biomolecular-screening-protein-technologies-unit

Research ethics committees for medicinal products (RECm) are independent of research project sponsors and researchers, and their purpose is to ensure the methodological, ethical and legal adequacy of any research project that involves a physical or psychological risk to a human being.

Contact: Cristina Llop
CEIC-PSMAR@imim.es

Web:
https://www.imim.es/comitesetics/ceic/es_index.html

The CBS-PRBB was set up on 2nd July, 2011, to regulate and supervise activities involving Genetically Modified Organisms (GMOs) undertaken within the PRBB environment. Its purpose is to evaluate the biosafety of scientific projects that employ GMOs or biological agents, as well as any chemical products that may have a particularly significant, complex or dangerous biological effect.

Contact: Secretaría
cbs@prbb.org

Web:
https://www.prbb.org (Acceso: Portal PRBB)

BiblioPRO is a virtual library of Health-Related Quality of Life (HRQL) questionnaires and other patient-reported outcomes (PRO), in Spanish, which can be accessed free of charge. It is intended to promote the appropriate use of HRQL instruments (in Spanish) in research, clinical practice and social-healthcare management, by providing comprehensive online information, evidence-based evaluations, and specialist training in this field. The library currently holds information on more than 500 questionnaires and is updated regularly.

Contact: Jordi Alonso
bibliopro@imim.es

Web:
https://www.bibliopro.org

The EGA provides a service for permanently archiving and distributing personally identifiable genetic and phenotypic data arising from biomedical research projects. The EGA data was obtained from individuals whose consent agreements authorise data disclosure only for use in specific research carried out by bona fide researchers. Strict protocols govern how the EGA project manages, stores, and distributes the information.

Contact: Arcadi Navarro
helpdesk@ega-archive.org

Web:
https://ega-archive.org

This service provides next generation microarray and sequencing technologies. Several high-throughput technologies enable the evaluation of differential expression, inter-individual gene variation, microRNA discovery, genome sequencing, targeted re-sequencing, epigenetic profiling and the identification of DNA- or RNA-associated protein binding sites. The microarray unit is equipped with the latest Agilent technology.

Contact: Jochen Hecht
ngs@crg.eu

Web:
https://www.crg.eu/en/programmes-groups/genomics-unit

The MARGenomics platform is primarily intended for translational research that integrates all phases of the genomic analysis process: from the initial assessment of the project, through sample processing, to the final data analysis and support for interpreting the results. This platform integrates structural and human resources from both the IMIM and Hospital del Mar and is coordinated with the MARBiobanc platform. It offers DNA analysis services, microarrays, next generation sequencing and data analysis.

Contact: Montserrat Torà
margenomics@imim.es

Web:
https://margenomics.imim.es

The platform offers a wide variety of methods for analysing DNA and RNA. The available equipment includes liquid-handling robots for automated pipetting tasks, capillary sequencers for Sanger sequencing and fragment analysis, DNA quantification and quality control with Picogreen and Bioanalyzer, real-time PCR and OpenArray system for the absolute and relative quantification of nucleic acids (genotyping and gene expression). It is also equipped with two state-of-the-art Illumina sequencing platforms: MiSeq, ideal for sequencing specific and small genomes; and NextSeq, a highly flexible platform able to perform a wide range of applications.

Contact: Ferran Casals
genomica@upf.edu

Web:
https://www.upf.edu/web/sct-genomics/home

The platform features the latest technologies used in the fields of stem cell biology, stem cell differentiation, organoid formation and induced pluripotent stem cells (iPSC). In collaboration with the Biomolecular Screening & Protein Technologies Unit at the CRG, the platform provides a CRISPR/Cas9 genome editing service.

Contact: Laura Batlle Morera
laura.batlle@crg.eu

Web:
https://www.crg.eu/en/programmes-groups/tissue-engineering-unit-0

This service is accredited by the Generalitat de Catalunya as a Phase I Clinical Trials Unit. Here, clinical trials with drugs are performed on healthy volunteers, nutritional studies are conducted and other support activities are carried out for developing trials in various therapeutic areas. The unit has space for 12 volunteers in the admissions area as well as three dispensaries for screening visits and outpatient evaluations. It has a high recruitment capacity due to its database of over 500 volunteers.

Contact: Ana Aldea
aaldea@imim.es

Web:
https://www.imim.es/ofertadeserveis/assajos_clinics

This platform enables 3D images to be taken of biological tissues over time. Mesoscopic microscopy involves looking at the details of biological systems in the context of an organ, body part or organism. It employs techniques such as selective plane illumination microscopy (SPIM) and optical projection tomography (OPT), which combine the capture of fine details with the ability to study relatively large samples over long periods of time.

Contact: Jim Swoger
mif@embl.es

Web:
https://www.embl.es/services/mesoscopic-imaging-facility

The unit is equipped with several advanced light microscopy systems, equipment for sample preparation and maintenance prior to imaging, and resources for the subsequent processing of the image data. Current imaging applications include super resolution microscopy, multiphoton microscopy, confocal microscopy, wide-field microscopy and detection microscopy.

Contact: Nadia Halidi
nadia.halidi@crg.eu

Web:
https://www.crg.eu/en/programmes-groups/advanced-light-microscopy-unit

Synthetic peptides are useful tools for applications involving immunogens (antipeptide antibodies, vaccines), affinity capture and purification ligands, intracellular administration shuttles and anti-infection therapies. The latest-generation equipment allows fast and reliable peptide synthesis in a wide range of sizes (up to 50 residues), quantities (1-500 mg), purities and forms (free, coupled to carrier proteins or affinity supports, biotinylated, lipidated, fluoro-labeled, etc.)

Contact: David Andreu
david.andreu@upf.edu

Web:
https://www.upf.edu/web/sct-peptide-synthesis

This unit provides proteomics services to both internal and external users, and develops quantitative techniques based on mass spectrometry. It formed part of the European Epic-XS Project infrastructure that brought together the top European proteomics laboratories and platforms to disseminate proteomics access and tools to the international community. The service is also part of the "Biomolecular and Bioinformatics Resource Platform" and "ProteoRed" from the Carlos III Health Institute, part of the Spanish National Health System.

Contact: Eduard Sabido Aguade
eduard.sabido@crg.eu

Web:
https://www.crg.eu/en/programmes-groups/crgupf-proteomics-unit


Scientific publications
(keywords, journal, author,...)

Factors associated with successful dietary changes in an energy-reduced Mediterranean diet intervention: a longitudinal analysis in the PREDIMED-Plus trial.

Fernandez-Lazaro CI, Toledo E, Buil-Cosiales P, Salas-Salvadó J, Corella D, Fitó M, Martínez JA, Alonso-Gómez ÁM, Wärnberg J, Vioque J, Romaguera D, López-Miranda J, Estruch R, Tinahones FJ, Lapetra J, Serra-Majem L, Bueno-Cavanillas A, Tur JA, Martín Sánchez V, Pintó X, Delgado-Rodríguez M, Matía-Martín P, Vidal J, Ros E, Vázquez C, Daimiel L, SanJulián B, García-Gavilán JF, Sorlí JV, Castañer O, Zulet MÁ, Tojal-Sierra L, Pérez-Farinós N, Oncina-Canovas A, Moñino M, Garcia-Rios A, Sacanella E, Bernal-Lopez RM, Santos-Lozano JM, Vázquez-Ruiz Z, Muralidharan J, Ortega-Azorín C, Goday A, Razquin C, Goicolea-Güemez L, Ruiz-Canela M, Becerra-Tomás N, Schröder H, Martínez González MA, PREDIMED-Plus investigators.

Eur J Nutr. 2021 Nov 30;

http://www.ncbi.nlm.nih.gov/en...

HLA-G genetic diversity and evolutive aspects in worldwide populations.

Castelli EC, de Almeida BS, Muniz YCN, Silva NSB, Passos MRS, Souza AS, Page AE, Dyble M, Smith D, Aguileta G, Bertranpetit J, Migliano AB, Duarte YAO, Scliar MO, Wang J, Passos-Bueno MR, Naslavsky MS, Zatz M, Mendes-Junior CT, Donadi EA

Sci Rep. 2021 Nov 29;11(1):23070

http://www.ncbi.nlm.nih.gov/en...

Combining schizophrenia and depression polygenic risk scores improves the genetic prediction of lithium response in bipolar disorder patients.

Schubert KO, Thalamuthu A, Amare AT, Frank J, Streit F, Adl M, Akula N, Akiyama K, Ardau R, Arias B, Aubry JM, Backlund L, Bhattacharjee AK, Bellivier F, Benabarre A, Bengesser S, Biernacka JM, Birner A, Marie-Claire C, Cearns M, Cervantes P, Chen HC, Chillotti C, Cichon S, Clark SR, Cruceanu C, Czerski PM, Dalkner N, Dayer A, Degenhardt F, Del Zompo M, DePaulo JR, Étain B, Falkai P, Forstner AJ, Frisen L, Frye MA, Fullerton JM, Gard S, Garnham JS, Goes FS, Grigoroiu-Serbanescu M, Grof P, Hashimoto R, Hauser J, Heilbronner U, Herms S, Hoffmann P, Hou L, Hsu YH, Jamain S, Jiménez E, Kahn JP, Kassem L, Kuo PH, Kato T, Kelsoe J, Kittel-Schneider S, Ferensztajn-Rochowiak E, König B, Kusumi I, Laje G, Landén M, Lavebratt C, Leboyer M, Leckband SG, Maj M, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium., Manchia M, Martinsson L, McCarthy MJ, McElroy S, Colom F, Mitjans M, Mondimore FM, Monteleone P, Nievergelt CM, Nöthen MM, Novák T, O'Donovan C, Ozaki N, Ösby U, Papiol S, Pfennig A, Pisanu C, Potash JB, Reif A, Reininghaus E, Rouleau GA, Rybakowski JK, Schalling M, Schofield PR, Schweizer BW, Severino G, Shekhtman T, Shilling PD, Shimoda K, Simhandl C, Slaney CM, Squassina A, Stamm T, Stopkova P, Tekola-Ayele F, Tortorella A, Turecki G, Veeh J, Vieta E, Witt SH, Roberts G, Zandi PP, Alda M, Bauer M, McMahon FJ, Mitchell PB, Schulze TG, Rietschel M, Baune BT

Transl Psychiatry. 2021 Nov 29;11(1):606

http://www.ncbi.nlm.nih.gov/en...

SWI/SNF and RSC remodeler complexes bind to MBF-dependent genes.

González-Medina A, Pazo E, Hidalgo E, Ayté J

Cell Cycle. 2021 Nov 29;:1-10

http://www.ncbi.nlm.nih.gov/en...

Inflammatory potential of diet and bone mineral density in a senior Mediterranean population: a cross-sectional analysis of PREDIMED-Plus study.

García-Gavilán JF, Paz-Graniel I, Babio N, Romaguera D, Martínez JA, Martin V, Martínez MÁ, Konieczna J, Ruiz-Canela M, de Paz Fernandez JA, Goday A, Martínez-González MÁ, Bulló M, Salas-Salvadó J

Eur J Nutr. 2021 Nov 29;

http://www.ncbi.nlm.nih.gov/en...

The role of growth and nutrition in the early origins of spirometric restriction in adult life: a longitudinal, multicohort, population-based study.

Voraphani N, Stern DA, Zhai J, Wright AL, Halonen M, Sherrill DL, Hallberg J, Kull I, Bergström A, Murray CS, Lowe L, Custovic A, Morgan WJ, Martinez FD, Melén E, Simpson A, Guerra S

Lancet Respir Med. 2021 Nov 26;

http://www.ncbi.nlm.nih.gov/en...

What is meant by case management for the return-to-work of workers with musculoskeletal disorders? A scoping review.

Soler-Font M, Ramada JM, Montero-Moraga JM, Palencia-Sánchez F, Merelles A, Macdonald EB, Serra C

Work. 2021 Nov 25;

http://www.ncbi.nlm.nih.gov/en...

Stem cell aging in the skeletal muscle: The importance of communication.

Hong X, Campanario S, Ramírez-Pardo I, Grima-Terrén M, Isern J, Muñoz-Cánoves P

Ageing Res Rev. 2021 Nov 21;73:101528

http://www.ncbi.nlm.nih.gov/en...

[Suicidal attempt and suicidal ideation during the COVID-19 pandemic compared to previous years].

Jerónimo MA, Piñar S, Samos P, Gonzalez AM, Bellsolà M, Sabaté A, León J, Aliart X, Martín LM, Aceña R, Pérez V, Córcoles D

Rev Psiquiatr Salud Ment. 2021 Nov 19;

http://www.ncbi.nlm.nih.gov/en...

Experts document about an adequate utilization of SYSADOAs in controversial clinical situations.

Monfort J, Carné X, Abarca B, Giménez S, Romera M, Möller I, Bibas M, Vitaloni M, Batlle A, Vergés J

Reumatol Clin (Engl Ed). 2021 Dec;17(10):595-600

http://www.ncbi.nlm.nih.gov/en...

Understanding parasite-brain microvascular interactions with engineered 3D blood-brain barrier models.

Long RKM, Piatti L, Korbmacher F, Bernabeu M

Mol Microbiol. 2021 Nov 27;

http://www.ncbi.nlm.nih.gov/en...

Impact of the COVID-19 pandemic: Community and hospital shared pharmaceutical care model. Satisfaction and acceptability of patients with HIV infection on antiretroviral treatment.

Molas ME, Knobel H, Ferrández O, de Antonio Cuscó M, Carballo Martínez N, Rodríguez Caba C, Luque S, Guelar A, Castañeda Espinosa S, Grau S

Rev Esp Quimioter. 2021 Nov 26;

http://www.ncbi.nlm.nih.gov/en...

Differences in breast cancer-risk factors between screen-detected and non-screen-detected cases (MCC-Spain study).

Hernández-García M, Molina-Barceló A, Vanaclocha-Espi M, Zurriaga Ó, Pérez-Gómez B, Aragonés N, Amiano P, Altzibar JM, Castaño-Vinyals G, Sala M, Ederra M, Martín V, Gómez-Acebo I, Vidal C, Tardón A, Marcos-Gragera R, Pollán M, Kogevinas M, Salas D

Cancer Causes Control. 2021 Nov 24;

http://www.ncbi.nlm.nih.gov/en...

T cell lymphoblastic lymphoma with uncommon CD20 expression.

Diez-Feijóo R, Rodríguez-Sevilla JJ, Salido M, Colomo L, Salar A

Int J Lab Hematol. 2021 Nov 24;

http://www.ncbi.nlm.nih.gov/en...

Mediterranean diet and adiposity in children and adolescents: A systematic review.

Lassale C, Fitó M, Morales-Suárez-Varela M, Moya A, Gómez SF, Schröder H

Obes Rev. 2021 Nov 23;:e13381

http://www.ncbi.nlm.nih.gov/en...

Nutrients and Dietary Approaches in Patients with Type 2 Diabetes Mellitus and Cardiovascular Disease: A Narrative Review.

Jiménez-Cortegana C, Iglesias P, Ribalta J, Vilariño-García T, Montañez L, Arrieta F, Aguilar M, Durán S, Obaya JC, Becerra A, Pedro-Botet J, Sánchez-Margalet V, On Behalf Of The Cardiovascular Disease Working Group Of The Spanish Society Of Diabetes Sed

Nutrients. 2021 Nov 19;13(11)

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The HIV-1 Nucleocapsid Regulates Its Own Condensation by Phase-Separated Activity-Enhancing Sequestration of the Viral Protease during Maturation.

Lyonnais S, Sadiq SK, Lorca-Oró C, Dufau L, Nieto-Marquez S, Escribà T, Gabrielli N, Tan X, Ouizougun-Oubari M, Okoronkwo J, Reboud-Ravaux M, Gatell JM, Marquet R, Paillart JC, Meyerhans A, Tisné C, Gorelick RJ, Mirambeau G

Viruses. 2021 Nov 19;13(11)

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Evolution of the Early Spliceosomal Complex-From Constitutive to Regulated Splicing.

Borao S, Ayté J, Hümmer S

Int J Mol Sci. 2021 Nov 18;22(22)

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Correction: Telford et al. Expanding the Geographic Characterisation of Epstein-Barr Virus Variation through Gene-Based Approaches. Microorganisms 2020, 8, 1686.

Telford M, Hughes DA, Juan D, Stoneking M, Navarro A, Santpere G

Microorganisms. 2021 Nov 11;9(11)

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Development of Breast Cancer Spheroids to Evaluate Cytotoxic Response to an Anticancer Peptide.

Cavaco M, Fraga P, Valle J, Andreu D, Castanho MARB, Neves V

Pharmaceutics. 2021 Nov 4;13(11)

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Sex-Specific Metabolic Pathways Were Associated with Alzheimer's Disease (AD) Endophenotypes in the European Medical Information Framework for AD Multimodal Biomarker Discovery Cohort.

Xu J, Green R, Kim M, Lord J, Ebshiana A, Westwood S, Baird AL, Nevado-Holgado AJ, Shi L, Hye A, Snowden SG, Bos I, Vos SJB, Vandenberghe R, Teunissen CE, Kate MT, Scheltens P, Gabel S, Meersmans K, Blin O, Richardson J, De Roeck EE, Engelborghs S, Sleegers K, Bordet R, Rami L, Kettunen P, Tsolaki M, Verhey FRJ, Alcolea D, Lleó A, Peyratout G, Tainta M, Johannsen P, Freund-Levi Y, Frölich L, Dobricic V, Frisoni GB, Molinuevo JL, Wallin A, Popp J, Martinez-Lage P, Bertram L, Blennow K, Zetterberg H, Streffer J, Visser PJ, Lovestone S, Proitsi P, Legido-Quigley C, On Behalf Of The European Medical Information Framework Consortium

Biomedicines. 2021 Nov 3;9(11)

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Prenatal Exposure to Nonpersistent Chemical Mixtures and Fetal Growth: A Population-Based Study.

van den Dries MA, Keil AP, Tiemeier H, Pronk A, Spaan S, Santos S, Asimakopoulos AG, Kannan K, Gaillard R, Guxens M, Trasande L, Jaddoe VWV, Ferguson KK

Environ Health Perspect. 2021 Nov;129(11):117008

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Accumulation of Paneth Cells in Early Colorectal Adenomas Is Associated with Beta-Catenin Signaling and Poor Patient Prognosis.

López-Arribillaga E, Yan B, Lobo-Jarne T, Guillén Y, Menéndez S, Andreu M, Bigas A, Iglesias M, Espinosa L

Cells. 2021 Oct 28;10(11)

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Dynamics and Predictors of Cognitive Impairment along the Disease Course in Multiple Sclerosis.

Lopez-Soley E, Martinez-Heras E, Andorra M, Solanes A, Radua J, Montejo C, Alba-Arbalat S, Sola-Valls N, Pulido-Valdeolivas I, Sepulveda M, Romero-Pinel L, Munteis E, Martínez-Rodríguez JE, Blanco Y, Martinez-Lapiscina EH, Villoslada P, Saiz A, Solana E, Llufriu S

J Pers Med. 2021 Oct 28;11(11)

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Effects of Wine and Tyrosol on the Lipid Metabolic Profile of Subjects at Risk of Cardiovascular Disease: Potential Cardioprotective Role of Ceramides.

Rodríguez-Morató J, Boronat A, Serreli G, Enríquez L, Gomez-Gomez A, Pozo OJ, Fitó M, de la Torre R

Antioxidants (Basel). 2021 Oct 25;10(11)

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Standardized Comparison of Cardiovascular Risk Factors Prevalence in Spanish Women and Men Living with HIV and in the General Population.

Camps-Vilaró A, Pérez-Fernández S, Subirana I, Teira R, Estrada V, Domingo P, Dégano IR, Marrugat J

J Pers Med. 2021 Oct 25;11(11)

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Comparative Analysis of Dalbavancin versus Other Antimicrobial Options for Gram-Positive Cocci Infections: Effectiveness, Hospital Stay and Mortality.

de Pablo-Miró M, Pujol-Ruiz S, Iftimie S, Arenas-Miras MDM, López-Montesinos I, Duran-Jordà X, Anglès A, Grau S, Horcajada JP

Antibiotics (Basel). 2021 Oct 24;10(11)

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De novo assembly and functional annotation of blood transcriptome of loggerhead turtle, and in silico characterization of peroxiredoxins and thioredoxins.

Hernández-Fernández J, Pinzón Velasco AM, López Barrera EA, Rodríguez Becerra MDP, Villanueva-Cañas JL, Alba MM, Mariño Ramírez L

PeerJ. 2021;9:e12395

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Warning: a short circuit has been detected in the prescription of PCSK9 inhibitors.

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Clin Investig Arterioscler. 2021 Nov-Dec;33(6):306-307

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Characterizing the Brain Structural Adaptations Across the Motherhood Transition.

Martínez-García M, Paternina-Die M, Desco M, Vilarroya O, Carmona S

Front Glob Womens Health. 2021;2:742775

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Antibody conversion rates to SARS-CoV-2 in saliva from children attending summer schools in Barcelona, Spain.

Dobaño C, Alonso S, Fernández de Sevilla M, Vidal M, Jiménez A, Pons Tomas G, Jairoce C, Melé Casas M, Rubio R, Hernández García M, Ruiz-Olalla G, Girona-Alarcón M, Barrios D, Santano R, Mitchell RA, Puyol L, Mayer L, Chi J, Rodrigo Melero N, Carolis C, Garcia-Miquel A, Bonet-Carne E, Claverol J, Cubells M, Fortuny C, Fumadó V, Jou C, Muñoz-Almagro C, Izquierdo L, Bassat Q, Gratacós E, Aguilar R, García-García JJ, Moncunill G, Jordan I

BMC Med. 2021 Nov 23;19(1):309

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Budget impact analysis of bevacizumab biosimilars for cancer treatment in adult patients in Spain.

Calleja MA, Albanell J, Aranda E, García-Foncillas J, Feliu A, Rivera F, Oyagüez I, Salinas-Ortega L, Soto Alvarez J

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Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states.

Triana S, Vonficht D, Jopp-Saile L, Raffel S, Lutz R, Leonce D, Antes M, Hernández-Malmierca P, Ordoñez-Rueda D, Ramasz B, Boch T, Jann JC, Nowak D, Hofmann WK, Müller-Tidow C, Hübschmann D, Alexandrov T, Benes V, Trumpp A, Paulsen M, Velten L, Haas S

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A Physician-in-the-Loop Approach by Means of Machine Learning for the Diagnosis of Lymphocytosis in the Clinical Laboratory.

Bigorra L, Larriba I, Gutiérrez-Gallego R

Arch Pathol Lab Med. 2021 Nov 24;

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Updates on the psychological and psychiatric aspects of the Ehlers-Danlos syndromes and hypermobility spectrum disorders.

Bulbena-Cabré A, Baeza-Velasco C, Rosado-Figuerola S, Bulbena A

Am J Med Genet C Semin Med Genet. 2021 Nov 22;

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Point-of-care hepatitis C testing and treatment strategy for people attending harm reduction and addiction centres for hepatitis C elimination.

Forns X, Colom J, García-Retortillo M, Quer JC, Lens S, Martró E, Domínguez-Hernández R, Casado MÁ, Buti M

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Testicular pain as a warning symptom of a symptomatic abdominal aortic aneurysm: case report and review of the literature.

Casajuana E, Clarà A, Grochowicz L, Vivas I, Mateos E, Calsina L

Ann Vasc Surg. 2021 Nov 19;

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Social Factors Influence Behavior in the Novel Object Recognition Task in a Mouse Model of Down Syndrome.

Sierra C, De Toma I, Cascio LL, Vegas E, Dierssen M

Front Behav Neurosci. 2021;15:772734

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Methods to Develop an in silico Clinical Trial: Computational Head-to-Head Comparison of Lisdexamfetamine and Methylphenidate.

Gutiérrez-Casares JR, Quintero J, Jorba G, Junet V, Martínez V, Pozo-Rubio T, Oliva B, Daura X, Mas JM, Montoto C

Front Psychiatry. 2021;12:741170

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Correction to: Specific Susceptibility to COVID-19 in Adults with Down Syndrome.

Illouz T, Biragyn A, Frenkel-Morgenstern M, Weissberg O, Gorohovski A, Merzon E, Green I, Iulita F, Flores-Aguilar L, Dierssen M, De Toma I, Lifshitz H, Antonarakis SE, Yu E, Herault Y, Potier MC, Botté A, Roper R, Sredni B, Sarid R, London J, Mobley W, Strydom A, Okun E

Neuromolecular Med. 2021 Nov 19;

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Genomic transformation and social organization during the Copper Age-Bronze Age transition in southern Iberia.

Villalba-Mouco V, Oliart C, Rihuete-Herrada C, Childebayeva A, Rohrlach AB, Fregeiro MI, Celdrán Beltrán E, Velasco-Felipe C, Aron F, Himmel M, Freund C, Alt KW, Salazar-García DC, García Atiénzar G, de Miguel Ibáñez MP, Hernández Pérez MS, Barciela V, Romero A, Ponce J, Martínez A, Lomba J, Soler J, Martínez AP, Avilés Fernández A, Haber-Uriarte M, Roca de Togores Muñoz C, Olalde I, Lalueza-Fox C, Reich D, Krause J, García Sanjuán L, Lull V, Micó R, Risch R, Haak W

Sci Adv. 2021 Nov 19;7(47):eabi7038

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Prevalence and risk factors for serositis in patients with systemic lupus erythematosus: A case-control study.

Gimeno-Torres L, Carrión-Barberà I, Durán X, Villegas E, Monfort J, Salman-Monte TC

Lupus. 2021 Nov 18;:9612033211049305

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Quantitative assessments of late radiation-induced skin and soft tissue toxicity and correlation with RTOG scales and biological equivalent dose in breast cancer.

Huang Y, Sanz J, Rodríguez N, Duran X, Martínez A, Li X, Foro P, Conde M, Zhao M, Liu F, Reig A, Dengra J, Membrive I, Pérez P, Algara M

Clin Transl Oncol. 2021 Nov 18;

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Intraoperative irradiation in breast cancer: preliminary results in 80 patients as partial breast irradiation or anticipated boost prior to hypo-fractionated whole breast irradiation.

Li X, Sanz J, Argudo N, Vernet-Tomas M, Rodríguez N, Torrent L, Fernández-Velilla E, Pera O, Huang Y, Nicolau P, Jiménez M, Segura M, Algara M

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Diversity, multifaceted evolution, and facultative saprotrophism in the European Batrachochytrium salamandrivorans epidemic.

Kelly M, Pasmans F, Muñoz JF, Shea TP, Carranza S, Cuomo CA, Martel A

Nat Commun. 2021 Nov 18;12(1):6688

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The European Genome-phenome Archive in 2021.

Freeberg MA, Fromont LA, D'Altri T, Romero AF, Ciges JI, Jene A, Kerry G, Moldes M, Ariosa R, Bahena S, Barrowdale D, Barbero MC, Fernandez-Orth D, Garcia-Linares C, Garcia-Rios E, Haziza F, Juhasz B, Llobet OM, Milla G, Mohan A, Rueda M, Sankar A, Shaju D, Shimpi A, Singh B, Thomas C, de la Torre S, Uyan U, Vasallo C, Flicek P, Guigo R, Navarro A, Parkinson H, Keane T, Rambla J

Nucleic Acids Res. 2021 Nov 17;

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The full (and necessary) integration of Occupational Health into Public Health.

García AM, Benavides FG, Ronda Pérez E, Delclos GL, Ruiz Frutos C

Rev Esp Salud Publica. 2021 Nov 17;95

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Cell-type- and region-specific modulation of cocaine seeking by micro-RNA-1 in striatal projection neurons.

Forget B, Garcia EM, Godino A, Rodriguez LD, Kappes V, Poirier P, Andrianarivelo A, Marchan ES, Allichon MC, Marias M, Vanhoutte P, Girault JA, Maldonado R, Caboche J

Mol Psychiatry. 2021 Nov 16;

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Polyphosphate degradation by Nudt3-Zn2+ mediates oxidative stress response.

Samper-Martín B, Sarrias A, Lázaro B, Pérez-Montero M, Rodríguez-Rodríguez R, Ribeiro MPC, Bañón A, Wolfgeher D, Jessen HJ, Alsina B, Clotet J, Kron SJ, Saiardi A, Jiménez J, Bru S

Cell Rep. 2021 Nov 16;37(7):110004

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Ambient Air Pollution in Relation to SARS-CoV-2 Infection, Antibody Response, and COVID-19 Disease: A Cohort Study in Catalonia, Spain (COVICAT Study).

Kogevinas M, Castaño-Vinyals G, Karachaliou M, Espinosa A, de Cid R, Garcia-Aymerich J, Carreras A, Cortés B, Pleguezuelos V, Jiménez A, Vidal M, O'Callaghan-Gordo C, Cirach M, Santano R, Barrios D, Puyol L, Rubio R, Izquierdo L, Nieuwenhuijsen M, Dadvand P, Aguilar R, Moncunill G, Dobaño C, Tonne C

Environ Health Perspect. 2021 Nov;129(11):117003

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Determination of up to twenty carboxylic acid containing compounds in clinically relevant matrices by o-benzylhydroxylamine derivatization and liquid chromatography-tandem mass spectrometry.

Gomez-Gomez A, Olesti E, Montero-San-Martin B, Soldevila A, Deschamps T, Pizarro N, de la Torre R, Pozo OJ

J Pharm Biomed Anal. 2021 Oct 29;208:114450

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Corrigendum: Immunological Impact of a Gluten-Free Dairy-Free Diet in Children With Kidney Disease: A Feasibility Study.

Pérez-Sáez MJ, Uffing A, Leon J, Murakami N, Watanabe A, Borges TJ, Sabbisetti VS, Cureton P, Kenyon V, Keating L, Yee K, Fernandes Satiro CA, Serena G, Hildebrandt F, Riella CV, Libermann TA, Wang M, Pascual J, Bonventre JV, Cravedi P, Fasano A, Riella LV

Front Immunol. 2021;12:798560

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IFN-gamma signaling in natural and therapy-induced anti-tumor responses.

Martínez-Sabadell A, Arenas EJ, Arribas J

Clin Cancer Res. 2021 Nov 16;

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Clustering of Aromatic Residues in Prion-like Domains Can Tune the Formation, State, and Organization of Biomolecular Condensates.

Holehouse AS, Ginell GM, Griffith D, Böke E

Biochemistry. 2021 Nov 16;

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Increased COVID-19 Mortality in People With Previous Cerebrovascular Disease: A Population-Based Cohort Study.

Lazcano U, Cuadrado-Godia E, Grau M, Subirana I, Martínez-Carbonell E, Boher-Massaguer M, Rodríguez-Campello A, Giralt-Steinhauer E, Fernández-Pérez I, Jiménez-Conde J, Roquer J, Ois Á

Stroke. 2021 Nov 16;:STROKEAHA121036257

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Multimorbidity patterns of chronic conditions and geriatric syndromes in older patients from the MoPIM multicentre cohort study.

Baré M, Herranz S, Roso-Llorach A, Jordana R, Violán C, Lleal M, Roura-Poch P, Arellano M, Estrada R, Nazco GJ, MoPIM study group.

BMJ Open. 2021 Nov 15;11(11):e049334

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Acute-to-Chronic Glycemic Ratio as a Predictor of COVID-19 Severity and Mortality.

Ramon J, Llauradó G, Güerri R, Climent E, Ballesta S, Benaiges D, López-Montesinos I, Navarro H, Fernández N, Carrera MJ, Mauricio D, Flores-Le Roux JA, Chillarón JJ

Diabetes Care. 2021 Nov 15;

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Perceived helpfulness of treatment for alcohol use disorders: Findings from the World Mental Health Surveys.

Degenhardt L, Bharat C, Chiu WT, Harris MG, Kazdin AE, Vigo DV, Sampson NA, Alonso J, Andrade LH, Bruffaerts R, Bunting B, Cardoso G, de Girolamo G, Florescu S, Gureje O, Haro JM, Hu C, Karam AN, Karam EG, Kovess-Masfety V, Lee S, Makanjuola V, McGrath JJ, Medina-Mora ME, Moskalewicz J, Navarro-Mateu F, Posada-Villa J, Rapsey C, Stagnaro JC, Tachimori H, Ten Have M, Torres Y, Williams DR, Zarkov Z, Kessler RC, WHO World Mental Health Survey collaborators, The WHO World Mental Health Survey collaborators are Sergio Aguilar-Gaxiola.

Drug Alcohol Depend. 2021 Nov 1;229(Pt B):109158

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Relevance of myocardial injury biomarkers to the prognosis of COVID-19 patients. Response.

Calvo-Fernández A, Marrugat J, Vaquerizo B

Rev Esp Cardiol (Engl Ed). 2021 Oct 19;

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The Proteomic Signature of Recombinant Growth Hormone in Recreational Athletes.

Esefeld M, Pastor A, de la Torre R, Barroso O, Aikin R, Sarwath H, Engelke R, Schmidt F, Suhre K

J Endocr Soc. 2021 Dec 1;5(12):bvab156

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Cardiovascular Benefits of Phenol-Enriched Virgin Olive Oils: New Insights from the Virgin Olive Oil and HDL Functionality (VOHF) Study.

Pedret A, Fernández-Castillejo S, Valls RM, Catalán Ú, Rubió L, Romeu M, Macià A, de Las Hazas MCL, Farràs M, Giralt M, Mosele JI, Martín-Peláez S, Remaley AT, Covas MI, Fitó M, Motilva MJ, Solà R

Mol Nutr Food Res. 2021 Nov 14;:e2170061

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Sustained safety and efficacy of ligelizumab in patients with chronic spontaneous urticaria: A one-year extension study.

Maurer M, Giménez-Arnau A, Bernstein JA, Chu CY, Danilycheva I, Hide M, Makris M, Metz M, Savic S, Sitz K, Soong W, Staubach P, Sussman G, Barve A, Burciu A, Hua E, Janocha R, Severin T

Allergy. 2021 Nov 13;

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Cohort description: Measures of early-life behaviour and later psychopathology in the LifeCycle Project - EU Child Cohort Network.

Nader JL, López-Vicente M, Julvez J, Guxens M, Cadman T, Elhakeem A, Järvelin MR, Rautio N, Miettunen J, El Marroun H, Melchior M, Heude B, Charles MA, Yang TC, McEachan RRC, Wright J, Polanska K, Carson J, Lin A, Rauschert S, Huang RC, Popovic M, Richiardi L, Corpeleijn E, Cardol M, Mikkola TM, Eriksson JG, Salika T, Inskip H, Vinther JL, Strandberg-Larsen K, Gürlich K, Grote V, Koletzko B, Vafeiadi M, Sunyer J, Jaddoe VWV, Harris JR

J Epidemiol. 2021 Nov 13;

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SARS-CoV-2 could be spread through hospital medication dispensed to patients: A prospective observational study.

Grau S, Ferrández O, Echeverría-Esnal D, Maldonado R, Puig B, Ramirez A, Canal M, Montero A, González C, Herranz M, Masclans JR, Horcajada JP, Padilla E

Medicine (Baltimore). 2021 Nov 12;100(45):e27592

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Impact of ceftolozane/tazobactam concentrations in continuous infusion against extensively drug-resistant Pseudomonas aeruginosa isolates in a hollow-fiber infection model.

Montero MM, Domene-Ochoa S, López-Causapé C, Luque S, Sorlí L, Campillo N, Padilla E, Prim N, Ferrer-Alapont L, Angulo-Brunet A, Grau S, Oliver A, Horcajada JP

Sci Rep. 2021 Nov 12;11(1):22178

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Prenatal exposure to persistent organic pollutants and childhood obesity: A systematic review and meta-analysis of human studies.

Stratakis N, Rock S, La Merrill MA, Saez M, Robinson O, Fecht D, Vrijheid M, Valvi D, Conti DV, McConnell R, Chatzi VL

Obes Rev. 2021 Nov 12;:e13383

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Previous disorders and depression outcomes in individuals with 12-month major depressive disorder in the World Mental Health surveys.

Roest AM, de Vries YA, Al-Hamzawi A, Alonso J, Ayinde OO, Bruffaerts R, Bunting B, Caldas de Almeida JM, de Girolamo G, Degenhardt L, Florescu S, Gureje O, Haro JM, Hu C, Karam EG, Kiejna A, Kovess-Masfety V, Lee S, McGrath JJ, Medina-Mora ME, Navarro-Mateu F, Nishi D, Piazza M, Posada-Villa J, Scott KM, Stagnaro JC, Stein DJ, Torres Y, Viana MC, Zarkov Z, Kessler RC, de Jonge P, WHO World Mental Health Survey collaborators.

Epidemiol Psychiatr Sci. 2021 Nov 11;30:e70

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Dose of furosemide before admission predicts diuretic efficiency and long-term prognosis in acute heart failure.

Blázquez-Bermejo Z, Farré N, Caravaca Perez P, Llagostera M, Morán-Fernández L, Fort A, de Juan Bagudá J, García-Cosio MD, Ruiz-Bustillo S, Delgado JF

ESC Heart Fail. 2021 Nov 11;

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A conserved expression signature predicts growth rate and reveals cell & lineage-specific differences.

Jiang Z, Generoso SF, Badia M, Payer B, Carey LB

PLoS Comput Biol. 2021 Nov 11;17(11):e1009582

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SCoV2-MD: a database for the dynamics of the SARS-CoV-2 proteome and variant impact predictions.

Torrens-Fontanals M, Peralta-García A, Talarico C, Guixà-González R, Giorgino T, Selent J

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Influence of PACE score and conduction disturbances in the incidence of early new onset atrial fibrillation after typical atrial flutter ablation.

Vallès E, Martí-Almor J, Grau N, Casteigt B, Benito B, Cabrera S, Alcalde O, Benito E, Bas D, Conejos J, Cabero P, Soler C, Duran X, Fan R, Jimenez J

J Cardiol. 2021 Nov 10;

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Early Hypertransaminasemia after Kidney Transplantation: Significance and Evolution According to Donor Type.

Solà-Porta E, Redondo-Pachón D, Arias-Cabrales C, Navazo D, Buxeda A, Burballa C, Crespo M, García-Retortillo M, Pascual J, Pérez-Sáez MJ

J Clin Med. 2021 Nov 4;10(21)

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Health impacts of the new WHO air quality guidelines in European cities.

Khomenko S, Cirach M, Pereira-Barboza E, Mueller N, Barrera-Gómez J, Rojas-Rueda D, de Hoogh K, Hoek G, Nieuwenhuijsen M

Lancet Planet Health. 2021 Nov;5(11):e764

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COVID-19 in Children with Down Syndrome: Data from the Trisomy 21 Research Society Survey.

Emes D, Hüls A, Baumer N, Dierssen M, Puri S, Russell L, Sherman SL, Strydom A, Bargagna S, Brandão AC, Costa ACS, Feany PT, Chicoine BA, Ghosh S, Rebillat AS, Sgandurra G, Valentini D, Rohrer TR, Levin J, Lakhanpaul M, On Behalf Of The Trisomy Research Society Covid-Initiative Study Group

J Clin Med. 2021 Oct 31;10(21)

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Severe Hypoalbuminemia at Admission Is Strongly Associated with Worse Prognosis in Older Adults with SARS-CoV-2 Infection.

Arnau-Barrés I, Pascual-Dapena A, López-Montesinos I, Gómez-Zorrilla S, Sorlí L, Herrero M, Nogués X, Navarro-Valls C, Ibarra B, Canchucaja L, da Costa Venancio E, Blasco-Hernando F, Cruz J, Vázquez O, Miralles R, García-Giralt N, Güerri-Fernández R

J Clin Med. 2021 Oct 31;10(21)

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A Collection of Designed Peptides to Target SARS-CoV-2 Spike RBD-ACE2 Interaction.

Fernandez-Fuentes N, Molina R, Oliva B

Int J Mol Sci. 2021 Oct 27;22(21)

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Effects of Albumin on Survival after a Hepatic Encephalopathy Episode: Randomized Double-Blind Trial and Meta-Analysis.

Ventura-Cots M, Simón-Talero M, Poca M, Ariza X, Masnou H, Sanchez J, Llop E, Cañete N, Martín-Llahí M, Amador A, Martínez J, Clemente-Sanchez A, Puente A, Torrens M, Alvarado-Tapias E, Napoleone L, Miquel-Planas M, Ardèvol A, Casas Rodrigo M, Calleja JL, Solé C, Soriano G, Genescà J

J Clin Med. 2021 Oct 23;10(21)

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Relationship between the Risk of Gastric Cancer and Adherence to the Mediterranean Diet According to Different Estimators. MCC-Spain Study.

Álvarez-Álvarez L, Vitelli-Storelli F, Rubín-García M, Aragonés N, Ardanaz E, Castaño-Vinyals G, Obón-Santacana M, Dierssen-Sotos T, Salas-Trejo D, Tardón A, Moleón JJJ, Alguacil J, Chirlaque MD, Pérez-Gómez B, Pollán M, Kogevinas M, Martín V

Cancers (Basel). 2021 Oct 21;13(21)

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Glycemic Dysregulations Are Associated With Worsening Cognitive Function in Older Participants at High Risk of Cardiovascular Disease: Two-Year Follow-up in the PREDIMED-Plus Study.

Gómez-Martínez C, Babio N, Júlvez J, Becerra-Tomás N, Martínez-González MÁ, Corella D, Castañer O, Romaguera D, Vioque J, Alonso-Gómez ÁM, Wärnberg J, Martínez JA, Serra-Majem L, Estruch R, Tinahones FJ, Lapetra J, Pintó X, Tur JA, López-Miranda J, Bueno-Cavanillas A, Gaforio JJ, Matía-Martín P, Daimiel L, Martín-Sánchez V, Vidal J, Vázquez C, Ros E, Dalsgaard S, Sayón-Orea C, Sorlí JV, de la Torre R, Abete I, Tojal-Sierra L, Barón-López FJ, Fernández-Brufal N, Konieczna J, García-Ríos A, Sacanella E, Bernal-López MR, Santos-Lozano JM, Razquin C, Alvarez-Sala A, Goday A, Zulet MA, Vaquero-Luna J, Diez-Espino J, Cuenca-Royo A, Fernández-Aranda F, Bulló M, Salas-Salvadó J

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Human CLA+ Memory T Cell and Cytokines in Psoriasis.

de Jesús-Gil C, Sans-de San Nicolàs L, García-Jiménez I, Ferran M, Pujol RM, Santamaria-Babí LF

Front Med (Lausanne). 2021;8:731911

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Mood Disturbances, Anxiety, and Impact on Quality of Life in Patients Admitted to Epilepsy Monitoring Units.

Rocamora R, Chavarría B, Pérez E, Pérez-Enríquez C, Barguilla A, Panadés-de Oliveira L, Principe A, Zucca R

Front Neurol. 2021;12:761239

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Multivariate Analysis and Modelling of multiple Brain endOphenotypes: Let's MAMBO!

Vilor-Tejedor N, Garrido-Martín D, Rodriguez-Fernandez B, Lamballais S, Guigó R, Gispert JD

Comput Struct Biotechnol J. 2021;19:5800-5810

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Developing an App to Screen for Dual Disorders: A Tool for Improving Treatment Services in Mexico.

Marín-Navarrete R, Torrens M, Toledo-Fernández A, Mestre-Pinto JI, Sánchez-Domínguez R, Pérez-Lopez A, Saracco-Alvarez R, Madrigal-De León EÁ, Szerman N

Front Psychiatry. 2021;12:697598

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ADHD Comorbidity Structure and Impairment: Results of the WHO World Mental Health Surveys International College Student Project (WMH-ICS).

Mak ADP, Lee S, Sampson NA, Albor Y, Alonso J, Auerbach RP, Baumeister H, Benjet C, Bruffaerts R, Cuijpers P, Ebert DD, Gutierrez-Garcia RA, Hasking P, Lapsley C, Lochner C, Kessler RC

J Atten Disord. 2021 Nov 10;:10870547211057275

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Multi-laboratory experiment PME11 for the standardization of phosphoproteome analysis.

Colomé N, Abian J, Aloria K, Arizmendi JM, Barceló-Batllori S, Braga-Lagache S, Burlet-Schiltz O, Carrascal M, Casal JI, Chicano-Gálvez E, Chiva C, Clemente LF, Elortza F, Estanyol JM, Fernandez-Irigoyen J, Fernández-Puente P, Fidalgo MJ, Froment C, Fuentes M, Fuentes-Almagro C, Gay M, Hainard A, Heller M, Hernández ML, Ibarrola N, Iloro I, Kieselbach T, Lario A, Locard-Paulet M, Marina-Ramírez A, Martín L, Morato-López E, Muñoz J, Navajas R, Odena MA, Odriozola L, de Oliveira E, Paradela A, Pasquarello C, de Los Rios V, Ruiz-Romero C, Sabidó E, Sánchez Del Pino M, Sancho J, Santamaría E, Schaeffer-Reiss C, Schneider J, de la Torre C, Valero ML, Vilaseca M, Wu S, Wu L, Ximénez de Embún P, Canals F, Corrales FJ, ProteoRed-ISCIII., EuPA.

J Proteomics. 2021 Nov 7;251:104409

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Textbook outcome and survival after gastric cancer resection with curative intent: A population-based analysis.

Dal Cero M, Román M, Grande L, Yarnoz C, Estremiana F, Gantxegi A, Codony C, Gobbini Y, Garsot E, Momblan D, González-Duaigües M, Luna A, Pérez N, Aldeano A, Fernández S, Olona C, Hermoso J, Pulido L, Sánchez-Cano JJ, Güell M, Salazar D, Gimeno M, Pera M, Spanish EURECCA Esophagogastric Cancer Group.

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PHQ-8 scores and estimation of depression prevalence - Author's reply.

Arias-de la Torre J, Vilagut G, Ronaldson A, Serrano-Blanco A, Alonso J

Lancet Public Health. 2021 Nov;6(11):e794

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Estimated all-day and evening whole-brain radiofrequency electromagnetic fields doses, and sleep in preadolescents.

Cabré-Riera A, van Wel L, Liorni I, Koopman-Verhoeff ME, Imaz L, Ibarluzea J, Huss A, Wiart J, Vermeulen R, Joseph W, Capstick M, Vrijheid M, Cardis E, Röösli M, Eeftens M, Thielens A, Tiemeier H, Guxens M

Environ Res. 2021 Oct 29;:112291

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Corrigendum to "Linezolid vs glycopeptides in the treatment of glycopeptide-susceptible Enterococcus faecium bacteraemia: A propensity score matched comparative study" [International Journal of Antimicrobial Agents, Volume 54, Issue 5 (2019) 572-578].

Echeverria-Esnal D, Sorli L, Prim N, Conde-Estévez D, Mateu-De Antonio J, Martin-Ontiyuelo C, Horcajada JP, Grau S

Int J Antimicrob Agents. 2021 Oct 28;:106455

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Impact of high-flow oxygen therapy during exercise in idiopathic pulmonary fibrosis: a pilot crossover clinical trial.

Badenes-Bonet D, Cejudo P, Rodó-Pin A, Martín-Ontiyuelo C, Chalela R, Rodríguez-Portal JA, Vázquez-Sánchez R, Gea J, Duran X, Caguana OA, Rodriguez-Chiaradia DA, Balcells E

BMC Pulm Med. 2021 Nov 8;21(1):355

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Single-Cell Transcriptional Changes In Neurodegenerative Diseases.

Ahmadi A, Gispert JD, Navarro A, Vilor-Tejedor N, Sadeghi I

Neuroscience. 2021 Nov 5;

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Recommendations for pharmacotranscriptomic profiling of drug response in CNS disorders.

Xicota L, De Toma I, Maffioletti E, Pisanu C, Squassina A, Baune BT, Potier MC, Stacey D, Dierssen M, European College of Neuropsychopharmacology (ECNP) Pharmacogenomics & Transcriptomics Thematic Workgroup.

Eur Neuropsychopharmacol. 2021 Nov 4;54:41-53

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Cost-effectiveness evaluation of the use of PCSK9 inhibitors.

Civeira F, Pedro-Botet J

Endocrinol Diabetes Nutr (Engl Ed). 2021 Jun-Jul;68(6):369-371

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From research to rapid response: mass COVID-19 testing by volunteers at the Centre for Genomic Regulation.

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Infection induced SARS-CoV-2 seroprevalence and heterogeneity of antibody responses in a general population cohort study in Catalonia Spain.

Karachaliou M, Moncunill G, Espinosa A, Castaño-Vinyals G, Jiménez A, Vidal M, Santano R, Barrios D, Puyol L, Carreras A, Mayer L, Rubio R, Cortés B, Pleguezuelos V, O'Callaghan-Gordo C, Fossati S, Rivas I, Casabonne D, Vrijheid M, Izquierdo L, Aguilar R, Basagaña X, Garcia-Aymerich J, de Cid R, Dobaño C, Kogevinas M

Sci Rep. 2021 Nov 3;11(1):21571

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Stress-dependent inhibition of polarized cell growth through unbalancing the GEF/GAP regulation of Cdc42.

Salat-Canela C, Carmona M, Martín-García R, Pérez P, Ayté J, Hidalgo E

Cell Rep. 2021 Nov 2;37(5):109951

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Determinants of mechanical restraint in an acute psychiatric care unit.

El-Abidi K, Moreno-Poyato AR, Toll Privat A, Corcoles Martinez D, Aceña-Domínguez R, Pérez-Solà V, Mané A

World J Psychiatry. 2021 Oct 19;11(10):854-863

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P-tau235: a novel biomarker for staging preclinical Alzheimer's disease.

Lantero-Rodriguez J, Snellman A, Benedet AL, Milà-Alomà M, Camporesi E, Montoliu-Gaya L, Ashton NJ, Vrillon A, Karikari TK, Gispert JD, Salvadó G, Shekari M, Toomey CE, Lashley TL, Zetterberg H, Suárez-Calvet M, Brinkmalm G, Rosa Neto P, Blennow K

EMBO Mol Med. 2021 Nov 2;:e15098

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Txikispora philomaios n. sp., n. g., a Micro-Eukaryotic Pathogen of Amphipods, Reveals Parasitism and Hidden Diversity in Class Filasterea.

Urrutia A, Mitsi K, Foster R, Ross S, Carr M, Ward GM, van Aerle R, Marigomez I, Leger MM, Ruiz-Trillo I, Feist SW, Bass D

J Eukaryot Microbiol. 2021 Nov 2;:e12875

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linus: Conveniently explore, share, and present large-scale biological trajectory data in a web browser.

Waschke J, Hlawitschka M, Anlas K, Trivedi V, Roeder I, Huisken J, Scherf N

PLoS Comput Biol. 2021 Nov 1;17(11):e1009503

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COVID-19 severity and mortality in patients with CLL: an update of the international ERIC and Campus CLL study.

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Leukemia. 2021 Nov 1;

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A Standard Set of Value-Based Patient-Centered Outcomes and Measures of Overall Health in Adults.

Gangannagaripalli J, Albagli A, Myers SN, Whittaker S, Joseph A, Clarke A, Matkin L, Alonso J, Byock I, van den Berg M, Canfield C, Chaplin J, Dapueto J, de Almedia Fleck MP, Sidey-Gibbons C, Hazelzet J, Hess R, Immonen K, Joyner S, Katz C, Kerrigan C, Lam C, Lunn J, McKenzie F, Roeves A, Stowell C, Switaj T, Tinsley M, Zimlichman E, Valderas JM

Patient. 2021 Nov 1;

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Mapping the Patient-Oriented Prostate Utility Scale From the Expanded Prostate Cancer Index Composite and the Short-Form Health Surveys.

Zamora V, Garin O, Pardo Y, Pont À, Gutiérrez C, Cabrera P, Gómez-Veiga F, Pijoan JI, Litwin MS, Ferrer M, Multicentric Spanish Group of Clinically Localized Prostate Cancer.

Value Health. 2021 Nov;24(11):1676-1685

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The mechanosensitive Piezo1 channel controls endosome trafficking for an efficient cytokinetic abscission.

Carrillo-Garcia J, Herrera-Fernández V, Serra SA, Rubio-Moscardo F, Vogel-Gonzalez M, Doñate-Macian P, Hevia CF, Pujades C, Valverde MA

Sci Adv. 2021 Oct 29;7(44):eabi7785

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The insecticides permethrin and chlorpyriphos show limited genotoxicity and no leukemogenic potential in human and murine hematopoietic stem progenitor cells.

Rodriguez-Cortez VC, Navarrete-Meneses MP, Molina O, Velasco-Hernandez T, Gonzalez J, Romecin P, Gutierrez-Aguera F, Roca-Ho H, Vinyoles M, Kowarz E, Marin P, Rodriguez-Perales S, Gomez-Marin C, Perez-Vera P, Cortes-Ledesma F, Bigas A, Terron A, Bueno C, Menendez P

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DeepMP: a deep learning tool to detect DNA base modifications on Nanopore sequencing data.

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Gentrification pathways and their health impacts on historically marginalized residents in Europe and North America: Global qualitative evidence from 14 cities.

Anguelovski I, Cole HVS, O'Neill E, Baró F, Kotsila P, Sekulova F, Pérez Del Pulgar C, Shokry G, García-Lamarca M, Argüelles L, Connolly JJ, Honey-Rosés J, López-Gay A, Fontán-Vela M, Matheney A, Oscilowicz E, Binet A, Triguero-Mas M

Health Place. 2021 Oct 27;72:102698

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Environmental noise exposure and emotional, aggressive, and attention-deficit/hyperactivity disorder-related symptoms in children from two European birth cohorts.

Essers E, Pérez-Crespo L, Foraster M, Ambrós A, Tiemeier H, Guxens M

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Cross talk between the upstream exon-intron junction and Prp2 facilitates splicing of non-consensus introns.

Hümmer S, Borao S, Guerra-Moreno A, Cozzuto L, Hidalgo E, Ayté J

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Whole-exome analysis in Tunisian Imazighen and Arabs shows the impact of demography in functional variation.

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Sci Rep. 2021 Oct 26;11(1):21125

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Glucose 6-P dehydrogenase delays the onset of frailty by protecting against muscle damage.

Arc-Chagnaud C, Salvador-Pascual A, Garcia-Dominguez E, Olaso-Gonzalez G, Correas AG, Serna E, Brioche T, Chopard A, Fernandez-Marcos PJ, Serrano M, Serrano AL, Muñoz-Cánoves P, Sebastiá V, Viña J, Gomez-Cabrera MC

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Soundtrack of life: an fMRI study.

Falcon C, Navarro-Plaza MC, Gramunt N, Arenaza-Urquijo EM, Grau-Rivera O, Cacciaglia R, González-de-Echavarria JM, Sánchez-Benavides G, Operto G, Knezevic I, Molinuevo JL, Gispert JD

Behav Brain Res. 2021 Oct 25;:113634

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Absence of relevant clinical effects of SARS-COV-2 on the affinity of hemoglobin for O2 in patients with COVID-19.

Pascual-Guàrdia S, Ferrer A, Díaz Ó, Caguana AO, Tejedor E, Bellido-Calduch S, Rodríguez-Chiaradia DA, Gea J

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Timing of Toenail Collection and Concentrations of Metals in Pancreatic Cancer. Evidence Against Disease Progression Bias.

Pumarega J, Camargo J, Gasull M, Olshan AF, Soliman A, Chen Y, Richardson D, Alguacil J, Poole C, Trasande L, Porta M, PANKRAS II Study Group.

Expo Health. 2021 Oct 22;:1-13

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Recommendations of the Spanish Society of Neurology for the prevention of stroke. Interventions on lifestyle and air pollution.

García Pastor A, López-Cancio Martínez E, Rodríguez-Yáñez M, Alonso de Leciñana M, Amaro S, Arenillas JF, Ayo-Martín O, Castellanos M, Fuentes B, Freijo MM, Gomis M, Gómez Choco M, Martínez Sánchez P, Morales A, Palacio-Portilla EJ, Segura T, Serena J, Vivancos-Mora J, Roquer J, Ad hoc committee of the Spanish Society of Neurology's Cerebrovascular Disease Study Group.

Neurologia (Engl Ed). 2021 Jun;36(5):377-387

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Development, equivalence study, and normative data of version B of the Spanish-language Free and Cued Selective Reminding Test.

Grau-Guinea L, Pérez Enríquez C, García-Escobar G, Arrondo Elizarán C, Pereira Cutiño B, Florido Santiago M, Piqué Candini J, Planas A, Paez M, Peña Casanova J, Sánchez-Benavides G

Neurologia (Engl Ed). 2021 Jun;36(5):353-360

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Harmonisation and Between-Country Differences of the Lifetime of Experiences Questionnaire in Older Adults.

Ourry V, Marchant NL, Schild AK, Coll-Padros N, Klimecki OM, Krolak-Salmon P, Goldet K, Reyrolle L, Bachelet R, Sannemann L, Meiberth D, Demnitz-King H, Whitfield T, Botton M, Lebahar J, Gonneaud J, de Flores R, Molinuevo JL, Jessen F, Vivien D, de la Sayette V, Valenzuela MJ, Rauchs G, Wirth M, Chételat G, Arenaza-Urquijo EM, Medit-Ageing Research Group.

Front Aging Neurosci. 2021;13:740005

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Retreatment with Hyaluronic Acid Viscosupplementation in Knee Osteoarthritis: Agreement between EUROVISCO Guidelines and Current Medical Practice.

Henrotin Y, Tits C, Paul J, Gramme P, Helleputte T, Migliore A, Richette P, Chevalier X, Monfort J, Diracoglu D, Bard H, Jerosch J, Baron D, Raghu R, Conrozier T

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Development of a Dendrimeric Peptide-Based Approach for the Differentiation of Animals Vaccinated with FlagT4G against Classical Swine Fever from Infected Pigs.

Bohórquez JA, Defaus S, Rosell R, Pérez-Simó M, Alberch M, Gladue DP, Borca MV, Andreu D, Ganges L

Viruses. 2021 Oct 2;13(10)

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An overview of the efficacy and safety of everolimus in adult solid organ transplant recipients.

Tedesco-Silva H, Saliba F, Barten MJ, De Simone P, Potena L, Gottlieb J, Gawai A, Bernhardt P, Pascual J

Transplant Rev (Orlando). 2021 Sep 24;:100655

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Acute stress and alcohol exposure during adolescence result in an anxious phenotype in adulthood: Role of altered glutamate/endocannabinoid transmission mechanisms.

Sánchez-Marín L, Flores-López M, Pastor A, Gavito AL, Suárez J, de la Torre R, Pavón FJ, de Fonseca FR, Serrano A

Prog Neuropsychopharmacol Biol Psychiatry. 2021 Oct 22;:110460

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CB1 receptor antagonist AM4113 reverts the effects of cannabidiol on cue and stress-induced reinstatement of cocaine-seeking behaviour in mice.

Luján MÁ, Alegre-Zurano L, Martín-Sánchez A, Cantacorps L, Valverde O

Prog Neuropsychopharmacol Biol Psychiatry. 2021 Oct 21;:110462

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Single-dose intravenous ferric carboxymaltose infusion versus multiple fractionated doses of intravenous iron sucrose in the treatment of post-operative anaemia in colorectal cancer patients: a randomised controlled trial.

Laso-Morales MJ, Vives R, Bisbe E, García-Erce JA, Muñoz M, Martínez-López F, Carol-Boeris F, Pontes-García C

Blood Transfus. 2021 Oct 15;

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Classical and Non-classical Fibrosis Phenotypes Are Revealed by Lung and Cardiac Like Microvascular Tissues On-Chip.

Akinbote A, Beltran-Sastre V, Cherubini M, Visone R, Hajal C, Cobanoglu D, Haase K

Front Physiol. 2021;12:735915

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The antimetastatic breast cancer activity of the viral protein-derived peptide vCPP2319 as revealed by cellular biomechanics.

Oliveira FD, Cavaco M, Figueira TN, Valle J, Neves V, Andreu D, Gaspar D, Castanho MARB

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First Description of Late-Onset Autoinflammatory Disease Due to Somatic NLRC4 Mosaicism.

Ionescu D, Peñín-Franch A, Mensa-Vilaró A, Castillo P, Hurtado-Navarro L, Molina-López C, Romero-Chala S, Plaza S, Fabregat V, Buján S, Marques J, Casals F, Yagüe J, Oliva B, Fernández-Pereira LM, Pelegrín P, Aróstegui JI

Arthritis Rheumatol. 2021 Oct 20;

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Mining drug-target and drug-adverse drug reaction databases to identify target-adverse drug reaction relationships.

Galletti C, Bota PM, Oliva B, Fernandez-Fuentes N

Database (Oxford). 2021 Oct 20;2021

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Ethics of DNA research on human remains: five globally applicable guidelines.

Alpaslan-Roodenberg S, Anthony D, Babiker H, Bánffy E, Booth T, Capone P, Deshpande-Mukherjee A, Eisenmann S, Fehren-Schmitz L, Frachetti M, Fujita R, Frieman CJ, Fu Q, Gibbon V, Haak W, Hajdinjak M, Hofmann KP, Holguin B, Inomata T, Kanzawa-Kiriyama H, Keegan W, Kelso J, Krause J, Kumaresan G, Kusimba C, Kusimba S, Lalueza-Fox C, Llamas B, MacEachern S, Mallick S, Matsumura H, Morales-Arce AY, Matuzeviciute GM, Mushrif-Tripathy V, Nakatsuka N, Nores R, Ogola C, Okumura M, Patterson N, Pinhasi R, Prasad SPR, Prendergast ME, Punzo JL, Reich D, Sawafuji R, Sawchuk E, Schiffels S, Sedig J, Shnaider S, Sirak K, Skoglund P, Slon V, Snow M, Soressi M, Spriggs M, Stockhammer PW, Szécsényi-Nagy A, Thangaraj K, Tiesler V, Tobler R, Wang CC, Warinner C, Yasawardene S, Zahir M

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Tricarboxylic acid cycle related-metabolites and risk of atrial fibrillation and heart failure.

Bulló M, Papandreou C, García-Gavilán J, Ruiz-Canela M, Li J, Guasch-Ferré M, Toledo E, Clish C, Corella D, Estruch R, Ros E, Fitó M, Lee CH, Pierce K, Razquin C, Arós F, Serra-Majem L, Liang L, Martínez-González MA, Hu FB, Salas-Salvadó J

Metabolism. 2021 Oct 19;:154915

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FA-nf: A Functional Annotation Pipeline for Proteins from Non-Model Organisms Implemented in Nextflow.

Vlasova A, Hermoso Pulido T, Camara F, Ponomarenko J, Guigó R

Genes (Basel). 2021 Oct 19;12(10)

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Unhappy While Depressed: Examining the Dimensionality, Reliability and Validity of the Subjective Happiness Scale in a Spanish Sample of Patients with Depressive Disorders.

Feliu-Soler A, de Diego-Adeliño J, Luciano JV, Iraurgi I, Alemany C, Puigdemont D, Pérez V, Portella MJ, Trujols J

Int J Environ Res Public Health. 2021 Oct 19;18(20)

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Long-term exposure to PM10 above WHO guidelines exacerbates COVID-19 severity and mortality.

Marquès M, Correig E, Ibarretxe D, Anoro E, Antonio Arroyo J, Jericó C, Borrallo RM, Miret M, Näf S, Pardo A, Perea V, Pérez-Bernalte R, Ramírez-Montesinos R, Royuela M, Soler C, Urquizu-Padilla M, Zamora A, Pedro-Botet J, STACOV-XULA research group., Masana L, Domingo JL

Environ Int. 2021 Oct 16;158:106930

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Modulation of Telomere Length by Mediterranean Diet, Caloric Restriction, and Exercise: Results from PREDIMED-Plus Study.

Fernández de la Puente M, Hernández-Alonso P, Canudas S, Marti A, Fitó M, Razquin C, Salas-Salvadó J

Antioxidants (Basel). 2021 Oct 12;10(10)

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Maternal preconception occupational exposure to cleaning products and disinfectants and offspring asthma.

Tjalvin G, Svanes Ø, Igland J, Bertelsen RJ, Benediktsdóttir B, Dharmage S, Forsberg B, Holm M, Janson C, Jõgi NO, Johannessen A, Malinovschi A, Pape K, Real FG, Sigsgaard T, Torén K, Vindenes HK, Zock JP, Schlünssen V, Svanes C

J Allergy Clin Immunol. 2021 Oct 11;

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Systemic Profiles of microRNAs, Redox Balance, and Inflammation in Lung Cancer Patients: Influence of COPD.

Qin L, Guitart M, Curull V, Sánchez-Font A, Duran X, Tang J, Admetlló M, Barreiro E

Biomedicines. 2021 Sep 29;9(10)

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Deprivation Index and Lifestyle: Baseline Cross-Sectional Analysis of the PREDIMED-Plus Catalonia Study.

Basora J, Villalobos F, Pallejà-Millán M, Babio N, Goday A, Zomeño MD, Pintó X, Sacanella E, Salas-Salvadó J

Nutrients. 2021 Sep 27;13(10)

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Impact of Generic Entry on Hospital Antimicrobial Use: A Retrospective Quasi-Experimental Interrupted Time Series Analysis.

Espona M, Echeverria-Esnal D, Hernandez S, Almendral A, Gómez-Zorrilla S, Limon E, Ferrandez O, Grau S

Antibiotics (Basel). 2021 Sep 24;10(10)

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Metformin Use and Cognitive Function in Older Adults With Type 2 Diabetes Following a Mediterranean Diet Intervention.

Soldevila-Domenech N, Cuenca-Royo A, Babio N, Forcano L, Nishi S, Vintró-Alcaraz C, Gómez-Martínez C, Jiménez-Murcia S, Fernández-Carrión R, Gomis-González M, Alvarez-Sala A, Carlos S, Pintó X, Corella D, Díez-Espino J, Castañer O, Fernández-Aranda F, Salas-Salvadó J, de la Torre R

Front Nutr. 2021;8:742586

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Invention and Pilot Study of the Efficacy and Safety of the SUPRAtube Device in Continuous Supraglottic Aspiration for Intubated and Mechanically Ventilated Patients.

Ramírez-Sarmiento A, Aya O, Cáceres-Rivera D, Reyes CF, Espitia A, Pizarro C, Gea J, Castillo VR, Orozco-Levi M

Med Devices (Auckl). 2021;14:287-297

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Association between biomarkers of tobacco consumption and lung cancer risk among daily smokers.

González-Marrón A, Martín-Sánchez JC, Pérez-Ortuño R, Fu M, Ballbè M, Cartanyà-Hueso À, Matilla-Santander N, Pascual JA, Fernández E, Martínez-Sánchez JM

Expert Rev Respir Med. 2021 Oct 25;:1-6

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Correction to: Reproducibility and accuracy of microscale thermophoresis in the NanoTemper Monolith: a multi laboratory benchmark study.

López-Méndez B, Baron B, Brautigam CA, Jowitt TA, Knauer SH, Uebel S, Williams MA, Sedivy A, Abian O, Abreu C, Adamczyk M, Bal W, Berger S, Buell AK, Carolis C, Daviter T, Fish A, Garcia-Alai M, Guenther C, Hamacek J, Holková J, Houser J, Johnson C, Kelly S, Leech A, Mas C, Matulis D, McLaughlin SH, Montserret R, Nasreddine R, Nehmé R, Nguyen Q, Ortega-Alarcón D, Perez K, Pirc K, Piszczek G, Podobnik M, Rodrigo N, Rokov-Plavec J, Schaefer S, Sharpe T, Southall J, Staunton D, Tavares P, Vanek O, Weyand M, Wu D

Eur Biophys J. 2021 Oct 15;

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Walking on common ground: a cross-disciplinary scoping review on the clinical utility of digital mobility outcomes.

Polhemus A, Ortiz LD, Brittain G, Chynkiamis N, Salis F, Gaßner H, Gross M, Kirk C, Rossanigo R, Taraldsen K, Balta D, Breuls S, Buttery S, Cardenas G, Endress C, Gugenhan J, Keogh A, Kluge F, Koch S, Micó-Amigo ME, Nerz C, Sieber C, Williams P, Bergquist R, de Basea MB, Buckley E, Hansen C, Mikolaizak AS, Schwickert L, Scott K, Stallforth S, van Uem J, Vereijken B, Cereatti A, Demeyer H, Hopkinson N, Maetzler W, Troosters T, Vogiatzis I, Yarnall A, Becker C, Garcia-Aymerich J, Leocani L, Mazzà C, Rochester L, Sharrack B, Frei A, Puhan M, Mobilise-D.

NPJ Digit Med. 2021 Oct 14;4(1):149

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Ancient DNA of the pygmy marmoset type specimen Cebuella pygmaea (Spix, 1823) resolves a taxonomic conundrum.

Boubli JP, Janiak MC, Porter LM, Torre S, Cortés-Ortiz L, Da Silva MNF, Rylands AB, Nash S, Bertuol F, Byrne H, Silva FE, Rohe F, Vries D, Beck RMD, Ruiz-Gartzia I, Kuderna LFK, Marques-Bonet T, Hrbek T, Farias IP, Van Heteren AH, Roos C

Zool Res. 2021 Nov 18;42(6):761-771

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Muscle repair after physiological damage relies on nuclear migration for cellular reconstruction.

Roman W, Pinheiro H, Pimentel MR, Segalés J, Oliveira LM, García-Domínguez E, Gómez-Cabrera MC, Serrano AL, Gomes ER, Muñoz-Cánoves P

Science. 2021 Oct 15;374(6565):355-359

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Worse outcome and distinct mutational pattern in follicular lymphoma with anti-HBc positivity.

Fernandez MC, Rodríguez-Sevilla JJ, Fernández-Ibarrondo L, Sanchez-Gonzalez B, Gibert J, Bento L, Garcia JF, Sancho JM, Diez-Feijóo R, Camacho L, García-Retortillo M, Gimeno E, Colomo L, Gutierrez A, Bellosillo B, Salar A

Blood Adv. 2021 Oct 14;

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Diagnostic radiological examinations and risk of intracranial tumours in adults-findings from the Interphone Study.

Auvinen A, Cardis E, Blettner M, Moissonnier M, Sadetzki S, Giles G, Johansen C, Swerdlow A, Cook A, Fleming S, Berg-Beckhoff G, Iavarone I, Parent ME, Woodward A, Tynes T, McBride M, Krewski D, Feyching M, Takebayashi T, Armstrong B, Hours M, Siemiatycki J, Lagorio S, Larsen SB, Schoemaker M, Klaeboe L, Lönn S, Schüz J, and the INTERPHONE study group.

Int J Epidemiol. 2021 Oct 14;

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STAG2 loss-of-function affects short-range genomic contacts and modulates the basal-luminal transcriptional program of bladder cancer cells.

Richart L, Lapi E, Pancaldi V, Cuenca-Ardura M, Pau EC, Madrid-Mencía M, Neyret-Kahn H, Radvanyi F, Rodríguez JA, Cuartero Y, Serra F, Le Dily F, Valencia A, Marti-Renom MA, Real FX

Nucleic Acids Res. 2021 Oct 14;

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Indirect Genetic Effects: A Cross-disciplinary Perspective on Empirical Studies.

Baud A, McPeek S, Chen N, Hughes KA

J Hered. 2021 Oct 13;

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TIGER: The gene expression regulatory variation landscape of human pancreatic islets.

Alonso L, Piron A, Morán I, Guindo-Martínez M, Bonàs-Guarch S, Atla G, Miguel-Escalada I, Royo R, Puiggròs M, Garcia-Hurtado X, Suleiman M, Marselli L, Esguerra JLS, Turatsinze JV, Torres JM, Nylander V, Chen J, Eliasson L, Defrance M, Amela R, MAGIC., Mulder H, Gloyn AL, Groop L, Marchetti P, Eizirik DL, Ferrer J, Mercader JM, Cnop M, Torrents D

Cell Rep. 2021 Oct 12;37(2):109807

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"Echocardiographic response" to sacubitril-valsartan: does it decrease defibrillation implantation, as well as the incidence of malignant arrhythmias? Response.

Belarte-Tornero LC, Mojón D, Farré N

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Do Redox Balance and Inflammatory Events Take Place in Mild Bronchiectasis? A Hint to Clinical Implications.

Qin L, Guitart M, Admetlló M, Esteban-Cucó S, Maiques JM, Xia Y, Zha J, Carbullanca S, Duran X, Wang X, Barreiro E

J Clin Med. 2021 Sep 30;10(19)

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Atrial Fibrillation in Heart Failure Is Associated with High Levels of Circulating microRNA-199a-5p and 22-5p and a Defective Regulation of Intracellular Calcium and Cell-to-Cell Communication.

Garcia-Elias A, Tajes M, Yañez-Bisbe L, Enjuanes C, Comín-Colet J, Serra SA, Fernández-Fernández JM, Aguilar-Agon KW, Reilly S, Martí-Almor J, Benito B

Int J Mol Sci. 2021 Sep 26;22(19)

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Chromosome X-wide Analysis of Positive Selection in Human Populations: Common and Private Signals of Selection and its Impact on Inactivated Genes and Enhancers.

Villegas-Mirón P, Acosta S, Nye J, Bertranpetit J, Laayouni H

Front Genet. 2021;12:714491

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A protocol to quantify chromatin compaction with confocal and super-resolution microscopy in cultured cells.

Martin L, Vicario C, Castells-García Á, Lakadamyali M, Neguembor MV, Cosma MP

STAR Protoc. 2021 Dec 17;2(4):100865

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The human hepatocyte TXG-MAPr: gene co-expression network modules to support mechanism-based risk assessment.

Callegaro G, Kunnen SJ, Trairatphisan P, Grosdidier S, Niemeijer M, den Hollander W, Guney E, Piñero Gonzalez J, Furlong L, Webster YW, Saez-Rodriguez J, Sutherland JJ, Mollon J, Stevens JL, van de Water B

Arch Toxicol. 2021 Dec;95(12):3745-3775

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Reduced cue-induced reinstatement of cocaine-seeking behavior in Plcb1 +/- mice.

Cabana-Domínguez J, Martín-García E, Gallego-Roman A, Maldonado R, Fernàndez-Castillo N, Cormand B

Transl Psychiatry. 2021 Oct 11;11(1):521

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Transanal Total Mesorectal Excision Versus Anterior Total Mesorectal Excision For Rectal Cancer: A Propensity-Score Matched, Population-Based Study In Catalonia, Spain.

Manchon-Walsh P, de Lacy FB, Pera M, Espin-Basany E, Targarona EM, Biondo S, Aliste L, Pallarès N, Tebé C, Pata F, Lacy AM, Guarga A, Borràs JM

Dis Colon Rectum. 2021 Oct 18;

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Routine provision of feedback from patient-reported outcome measurements to healthcare providers and patients in clinical practice.

Gibbons C, Porter I, Gonçalves-Bradley DC, Stoilov S, Ricci-Cabello I, Tsangaris E, Gangannagaripalli J, Davey A, Gibbons EJ, Kotzeva A, Evans J, van der Wees PJ, Kontopantelis E, Greenhalgh J, Bower P, Alonso J, Valderas JM

Cochrane Database Syst Rev. 2021 Oct 12;10:CD011589

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Cross-Sectional Associations Between HDL Structure or Function, Cell Membrane Fatty Acid Composition, and Inflammation in Elderly Adults.

Muralidharan J, Papandreou C, Soria-Florido MT, Sala-Vila A, Blanchart G, Estruch R, Martínez-González MA, Corella D, Ros E, Ruiz-Canela M, Fito M, Salas-Salvadó J, Bulló M

J Nutr. 2021 Oct 12;

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Correction: Characterization of Anorexia Nervosa on Social Media: Textual, Visual, Relational, Behavioral, and Demographical Analysis.

Ramírez-Cifuentes D, Freire A, Baeza-Yates R, Sanz Lamora N, Álvarez A, González-Rodríguez A, Lozano Rochel M, Llobet Vives R, Velazquez DA, Gonfaus JM, Gonzàlez J

J Med Internet Res. 2021 Oct 12;23(10):e33447

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Tapentadol effects on brain response to pain in sensitized patients with knee osteoarthritis.

Pujol J, Martínez-Vilavella G, Doreste A, Blanco-Hinojo L, Ojeda F, Llorente-Onaindia J, Polino L, Deus J, Monfort J

Rheumatology (Oxford). 2021 Oct 12;

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Societal and equity challenges for Brain Health Services. A user manual for Brain Health Services-part 6 of 6.

Milne R, Altomare D, Ribaldi F, Molinuevo JL, Frisoni GB, Brayne C, European Task Force for Brain Health Services.

Alzheimers Res Ther. 2021 Oct 11;13(1):173

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Dementia risk communication. A user manual for Brain Health Services-part 3 of 6.

Visser LNC, Minguillon C, Sánchez-Benavides G, Abramowicz M, Altomare D, Fauria K, Frisoni GB, Georges J, Ribaldi F, Scheltens P, van der Schaar J, Zwan M, van der Flier WM, Molinuevo JL

Alzheimers Res Ther. 2021 Oct 11;13(1):170

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Brain Health Services: organization, structure, and challenges for implementation. A user manual for Brain Health Services-part 1 of 6.

Altomare D, Molinuevo JL, Ritchie C, Ribaldi F, Carrera E, Dubois B, Jessen F, McWhirter L, Scheltens P, van der Flier WM, Vellas B, Démonet JF, Frisoni GB, European Task Force for Brain Health Services.

Alzheimers Res Ther. 2021 Oct 11;13(1):168

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Protocols for cognitive enhancement. A user manual for Brain Health Services-part 5 of 6.

Brioschi Guevara A, Bieler M, Altomare D, Berthier M, Csajka C, Dautricourt S, Démonet JF, Dodich A, Frisoni GB, Miniussi C, Molinuevo JL, Ribaldi F, Scheltens P, Chételat G

Alzheimers Res Ther. 2021 Oct 11;13(1):172

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Modifiable risk factors for dementia and dementia risk profiling. A user manual for Brain Health Services-part 2 of 6.

Ranson JM, Rittman T, Hayat S, Brayne C, Jessen F, Blennow K, van Duijn C, Barkhof F, Tang E, Mummery CJ, Stephan BCM, Altomare D, Frisoni GB, Ribaldi F, Molinuevo JL, Scheltens P, Llewellyn DJ, European Task Force for Brain Health Services.

Alzheimers Res Ther. 2021 Oct 11;13(1):169

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The genetic impact of an Ebola outbreak on a wild gorilla population.

Fontsere C, Frandsen P, Hernandez-Rodriguez J, Niemann J, Scharff-Olsen CH, Vallet D, Le Gouar P, Ménard N, Navarro A, Siegismund HR, Hvilsom C, Gilbert MTP, Kuhlwilm M, Hughes D, Marques-Bonet T

BMC Genomics. 2021 Oct 11;22(1):735

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Revised International Prognostic Index and genetic alterations are associated with early failure to R-CHOP in patients with diffuse large B-cell lymphoma.

Dlouhy I, Karube K, Enjuanes A, Salaverria I, Nadeu F, Ramis-Zaldivar JE, Valero JG, Rivas-Delgado A, Magnano L, Martin-García D, Pérez-Galán P, Clot G, Rovira J, Jares P, Balagué O, Giné E, Mozas P, Briones J, Sancho JM, Salar A, Mercadal S, Alcoceba M, Valera A, Campo E, López-Guillermo A

Br J Haematol. 2021 Oct 10;

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A Large Multicenter Prospective Study of Community-Onset Healthcare Associated Bacteremic Urinary Tract Infections in the Era of Multidrug Resistance: Even Worse than Hospital Acquired Infections?

Gómez-Zorrilla S, Becerra-Aparicio F, López Montesinos I, Ruiz de Gopegui E, Grau I, Pintado V, Padilla B, Benito N, Boix-Palop L, Fariñas MC, Peñaranda M, Gamallo MR, Martinez JA, Morte-Romea E, Del Pozo JL, Durán-Jordá X, Díaz-Regañón J, López-Mendoza D, Cantón R, Oliver A, Ruiz-Garbajosa P, Horcajada JP, REIPI/GEIRAS-GEMARA SEIMC ITUBRAS-2 Group.

Infect Dis Ther. 2021 Oct 9;

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Molecular characterization of triple negative breast cancer formaldehyde-fixed paraffin-embedded samples by data-independent acquisition proteomics.

García-Adrián S, Trilla-Fuertes L, Gámez-Pozo A, Chiva C, López-Vacas R, López-Camacho E, Zapater-Moros A, Lumbreras-Herrera MI, Hardisson D, Yébenes L, Zamora P, Sabidó E, Fresno Vara JÁ, Espinosa E

Proteomics. 2021 Oct 8;:e2100110

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Changes in melatonin and sex steroid hormone production among men as a result of rotating night shift work - the HORMONIT study.

Harding BN, Castaño-Vinyals G, Palomar-Cros A, Papantoniou K, Espinosa A, Skene DJ, Middleton B, Gomez-Gomez A, Navarrete JM, Faro PS, Torrejón A, Kogevinas M, Pozo OJ

Scand J Work Environ Health. 2021 Oct 8;

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Prenatal exposure to fluoride and neuropsychological development in early childhood: 1-to 4 years old children.

Ibarluzea J, Gallastegi M, Santa-Marina L, Jiménez Zabala A, Arranz E, Molinuevo A, Lopez-Espinosa MJ, Ballester F, Villanueva CM, Riano I, Sunyer J, Tardon A, Lertxundi A

Environ Res. 2021 Oct 8;:112181

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Fulvestrant-Palbociclib vs Letrozole-Palbociclib as Initial Therapy for Endocrine-Sensitive, Hormone Receptor-Positive, ERBB2-Negative Advanced Breast Cancer: A Randomized Clinical Trial.

Llombart-Cussac A, Pérez-García JM, Bellet M, Dalenc F, Gil-Gil M, Ruíz-Borrego M, Gavilá J, Sampayo-Cordero M, Aguirre E, Schmid P, Marmé F, Di Cosimo S, Gligorov J, Schneeweiss A, Albanell J, Zamora P, Wheatley D, Martínez-de Dueñas E, Amillano K, Malfettone A, Cortés J, PARSIFAL Steering Committee and Trial Investigators.

JAMA Oncol. 2021 Oct 7;

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E3 ubiquitin ligase Atrogin-1 mediates adaptive resistance to KIT-targeted inhibition in gastrointestinal stromal tumor.

García-Valverde A, Rosell J, Sayols S, Gómez-Peregrina D, Pilco-Janeta DF, Olivares-Rivas I, de Álava E, Maurel J, Rubió-Casadevall J, Esteve A, Gut M, Valverde C, Barretina J, Carles J, Demetri GD, Fletcher JA, Arribas J, Serrano C

Oncogene. 2021 Oct 7;

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Application of the iBox prognostication system as a surrogate endpoint in the TRANSFORM randomised controlled trial: proof-of-concept study.

Aubert O, Divard G, Pascual J, Oppenheimer F, Sommerer C, Citterio F, Tedesco H, Chadban S, Henry M, Vincenti F, Srinivas T, Watarai Y, Legendre C, Bernhardt P, Loupy A

BMJ Open. 2021 Oct 7;11(10):e052138

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The effect of short term exposure to outdoor air pollution on fertility.

González-Comadran M, Jacquemin B, Cirach M, Lafuente R, Cole-Hunter T, Nieuwenhuijsen M, Brassesco M, Coroleu B, Checa MA

Reprod Biol Endocrinol. 2021 Oct 6;19(1):151

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Process evaluation of a complex workplace intervention to prevent musculoskeletal pain in nursing staff: results from INTEVAL_Spain.

Soler-Font M, Ramada JM, Merelles A, Amat A, de la Flor C, Martínez O, Palma-Vasquez C, Sancho C, Peña P, Bültmann U, van Zon SKR, Serra C

BMC Nurs. 2021 Oct 6;20(1):189

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Green space and mortality in European cities: a health impact assessment study.

Barboza EP, Cirach M, Khomenko S, Iungman T, Mueller N, Barrera-Gómez J, Rojas-Rueda D, Kondo M, Nieuwenhuijsen M

Lancet Planet Health. 2021 Oct;5(10):e718-e730

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Engineering a genome-reduced bacterium to eliminate Staphylococcus aureus biofilms in vivo.

Garrido V, Piñero-Lambea C, Rodriguez-Arce I, Paetzold B, Ferrar T, Weber M, Garcia-Ramallo E, Gallo C, Collantes M, Peñuelas I, Serrano L, Grilló MJ, Lluch-Senar M

Mol Syst Biol. 2021 Oct;17(10):e10145

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Mobile Device-assisted Dietary Ecological Momentary Assessments for the Evaluation of the Adherence to the Mediterranean Diet in a Continuous Manner.

Boronat A, Clivillé-Pérez J, Soldevila-Domenech N, Forcano L, Pizarro N, Fitó M, Schröder H, Fauria K, de la Torre R

J Vis Exp. 2021 Sep 25;(175)

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Clinical experience of TB in patients treated with anti-TNF-alfa.

Arenas-Miras M, Sánchez-Martínez F, Jové-Caballé N, Villar-García J, López-Montesinos I, Grau S, Carballo N, Knobel-Freud H, Horcajada JP

Int J Tuberc Lung Dis. 2021 Oct 1;25(10):866-868

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[Potential Limitations in the Use of Arterial Oxygen Pressure in Respiratory Disorders Produced by SARS-CoV-2].

Gea J, Ferrer A, Martínez-Llorens JM

Arch Bronconeumol. 2020 Jul;56:9-10

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The Role of Hydrophobic Nodes in the Dynamics of Class A Beta-Lactamases.

Olehnovics E, Yin J, Pérez A, De Fabritiis G, Bonomo RA, Bhowmik D, Haider S

Front Microbiol. 2021;12:720991

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WHO Air Quality Guidelines 2021-Aiming for Healthier Air for all: A Joint Statement by Medical, Public Health, Scientific Societies and Patient Representative Organisations.

Hoffmann B, Boogaard H, de Nazelle A, Andersen ZJ, Abramson M, Brauer M, Brunekreef B, Forastiere F, Huang W, Kan H, Kaufman JD, Katsouyanni K, Krzyzanowski M, Kuenzli N, Laden F, Nieuwenhuijsen M, Mustapha A, Powell P, Rice M, Roca-Barceló A, Roscoe CJ, Soares A, Straif K, Thurston G

Int J Public Health. 2021;66:1604465

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Environmental risk factors and cardiovascular diseases: a comprehensive review.

Münzel T, Hahad O, Sørensen M, Lelieveld J, Duerr GD, Nieuwenhuijsen M, Daiber A

Cardiovasc Res. 2021 Oct 5;

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Healthy cities after COVID-19 pandemic: the just ecofeminist healthy cities approach.

Triguero-Mas M, Anguelovski I, Cole HVS

J Epidemiol Community Health. 2021 Oct 4;

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Relevance of myocardial injury biomarkers to the prognosis of COVID-19 patients. Response.

Calvo-Fernández A, Marrugat J, Vaquerizo B

Rev Esp Cardiol. 2021 Sep 27;

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Individual and population level estimates of work loss and related economic costs due to mental and substance use disorders in Metropolitan São Paulo, Brazil.

França MH, Pereira FG, Wang YP, Andrade LH, Alonso J, Viana MC

J Affect Disord. 2021 Sep 25;296:198-207

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Combined Molecular and Elemental Mass Spectrometry Approaches for Absolute Quantification of Proteomes: Application to the Venomics Characterization of the Two Species of Desert Black Cobras, Walterinnesia aegyptia and Walterinnesia morgani.

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Salmonella enterica from a soldier from the 1652 siege of Barcelona (Spain) supports historical transatlantic epidemic contacts.

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The International EAACI/GA²LEN/EuroGuiDerm/APAAACI Guideline for the Definition, Classification, Diagnosis and Management of Urticaria.

Zuberbier T, Abdul Latiff AH, Abuzakouk M, Aquilina S, Asero R, Baker D, Ballmer-Weber B, Bangert C, Ben-Shoshan M, Bernstein JA, Bindslev-Jensen C, Brockow K, Brzoza Z, Chong Neto HJ, Church MK, Criado PR, Danilycheva IV, Dressler C, Ensina LF, Fonacier L, Gaskins M, Gáspár K, Gelincik A, Giménez-Arnau A, Godse K, Gonçalo M, Grattan C, Grosber M, Hamelmann E, Hébert J, Hide M, Kaplan A, Kapp A, Kessel A, Kocatürk E, Kulthanan K, Larenas-Linnemann D, Lauerma A, Leslie TA, Magerl M, Makris M, Meshkova RY, Metz M, Micallef D, Mortz CG, Nast A, Oude-Elberink H, Pawankar R, Pigatto PD, Ratti Sisa H, Rojo Gutiérrez MI, Saini SS, Schmid-Grendelmeier P, Sekerel BE, Siebenhaar F, Siiskonen H, Soria A, Staubach-Renz P, Stingeni L, Sussman G, Szegedi A, Thomsen SF, Vadasz Z, Vestergaard C, Wedi B, Zhao Z, Maurer M

Allergy. 2021 Sep 18;

http://www.ncbi.nlm.nih.gov/en...

Are Cutibacterium acnes present at the end of primary shoulder prosthetic surgeries responsible for infection? Prospective study.

Torrens C, Bellosillo B, Gibert J, Alier A, Santana F, Prim N, Corvec S

Eur J Clin Microbiol Infect Dis. 2021 Sep 17;

http://www.ncbi.nlm.nih.gov/en...


Good practice

Top quality research with the utmost integrity

The international scientific community is increasingly aware of maintaining high standards of good scientific practice and integrity in research. To this end, research institutes around the world are developing and adhering to codes of good practice that establish scientific norms and quality standards.

At the PRBB, we aim to create an environment conducive to high quality research performed with the utmost integrity. To raise awareness of this and help prevent malpractice in science, we have established:

  • The PRBB Code of Good Scientific Practices, approved by all the centres.
  • An inter-centre working group for sharing lessons learned and good practices in scientific integrity between the PRBB centres.
  • Training in scientific integrity: all Biomedicine PhD students at Pompeu Fabra University (UPF) must take the "Science in Action” course. In addition, the PRBB and its centres organise various courses related to good scientific practice for its staff, and the PRBB also offers introductory workshops on scientific integrity for external organisations.

To learn more about the code, the working group on good scientific practices and the various activities organised, visit:


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Innovation

Patents and companies

  • The following links allow you to explore the technology on offer in the park’s centres:

Technology at the IMIM-Hospital del Mar

→ https://www.imim.es/en_dareaestrategica.html

UPF Business Shuttle and Innovation Unit

→ www.upf.edu/web/innovacio

Technology and Business Development Office at the CRG

→ https://tbdo.crg.eu

Analysis and Global Development at ISGlobal

→ www.isglobal.org/es/policy-and-development

EMBLEM Technology Transfer

→ https://embl-em.de

  • The following start-ups have been created within the PRBB environment:

Acellera

Acellera is dedicated to developing cutting-edge applications for the computational discovery of drugs. In 2019, Acellera was named one of the Top 30 "AI Drug Discovery" companies in the world.

→ https://www.acellera.com

Chemotargets

Chemotargets is a world leader in artificial intelligence solutions and predictive analytics for better and safer drug discovery. The goal of this spin-off from IMIM is to help the biopharmaceutical industry accelerate drug discovery and development programmes.

→ http://www.chemotargets.com/

qGenomics

qGenomics is a biotechnology company operating in the genetic diagnosis market and based in Barcelona. They have created a sustainable and responsible business aimed at bringing together genomic research and clinical application to help all citizens.

→ https://qgenomics.com

ZeClinics

ZeClinics is a biotechnology CRO (Contract Research Organisation) and an early stage biopharmaceutical company (Pharma) that uses zebrafish (Danio rerio) to detect the safety and efficacy of new chemical molecules.

→ http://www.zeclinics.com

Microomics

Microomics is a biotechnology-based spin-off that provides innovative metagenomic and genomic solutions to traditional and novel issues in the Pharmaceutical, Healthcare, Agri-Food, Consumer Goods and Environmental sectors.

→ http://www.microomics.eu

Flomics

World leaders in fluid transcriptomics. Flomics was created by a group of genomics researchers with the goal of transforming laboratory discoveries into better healthcare for society.

→ http://www.flomics.com

Bioinspired Materials

This UPF spin-off company seeks to reduce the impact of pig waste by extracting molecules that are useful for producing feed, adhesives and binding materials.

→ http://biom.tech

MedBioinformatics Solutions

MedBioinformatics Solutions are based on DisGeNET, a tool developed by the GRIB (IMIM-UPF). It stores 600,000 associations between more than 17,000 genes and 24,000 human diseases.

→ http://www.disgenetplus.com/medbioinformatics/

Pulmobiotics

A spin off company from the CRG founded by experienced entrepreneurs and funded by invivo Ventures. Pulmobiotics will use its technology to discover and develop novel treatments and vaccines for respiratory diseases.

→ https://www.pulmobio.com/

Integra Therapeutics

Integra Therapeutics, a spin-off company from DCEXS-UPF by Marc Güell, has combined the precision of CRISPR systems with the gene transfer efficiency of viral integrases and transposases in the patented new genome editing technology Uni-large.

→ https://integra-tx.com/

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